Dow Lab

The Dow Laboratory investigates tumor immune responses and develops new cancer immunotherapies. The laboratory also develops immunotherapies to prevent respiratory tract infections in cattle, dogs and cats, as well as for treatment of ocular viral infections and ocular cancer in horses and cats. A third program focuses on stem cell therapy for treatment of chronic infections and for wound healing, with studies in rodent models and pet dogs.

research project

Cancer Immunotherapy

Studies investigating the use of oral immunotherapies and tumor vaccines for bone cancer and brain cancer in dogs, and in mouse models. Investigation of CAR T cell therapy for treatment of bone cancer metastases in dogs. New immunotherapies for treatment of corneal cancer investigated using horse cancer model.

research project

Biological therapies for treatment of osteoarthritis and tendon injuries

Studies using rodent and large animal models to investigate new means of engaging the immune system to stimulate tendon healing and control progression of chronic osteoarthritis.

research project

New diagnostics for GI diseases

New molecular tools being developed for non-invasive diagnosis of inflammatory bowel disease and cancer, using studies in dogs, cats, and humans.

research project

New mucosal vaccine technologies

Development of intranasal vaccines for Covid and other viral diseases, using novel mucosal vaccine adjuvant and delivery technologies.

Publications

Losartan Blocks Osteosarcoma-Elicited Monocyte Recruitment, and Combined With the Kinase Inhibitor Toceranib, Exerts Significant Clinical Benefit in Canine Metastatic Osteosarcoma

Regan DP, Chow L, Das S, Haines L, Palmer E, Kurihara JN, Coy JW, Mathias A, Thamm DH, Gustafson DL, Dow SW. Clin Cancer Res. 2022 Feb 15;28(4):662-676. doi: 10.1158/1078-0432.CCR-21-2105. PMID: 34580111; PMCID: PMC8866227.

Novel ocular immunotherapy induces tumor regression in an equine model of ocular surface squamous neoplasia

Wotman KL, Chow L, Martabano B, Pezzanite LM, Dow S. Cancer Immunol Immunother. 2022 Nov 11. doi: 10.1007/s00262-022-03321-2. Epub ahead of print. PMID: 36367558.

Canine polarized macrophages express distinct functional and transcriptomic profiles

Chow L, Soontararak S, Wheat W, Ammons D, Dow S. Front Vet Sci. 2022 Nov 1;9:988981. doi: 10.3389/fvets.2022.988981. PMID: 36387411; PMCID: PMC9663804.

Non-specific protection from respiratory tract infections in cattle generated by intranasal administration of an innate immune stimulant

Wheat W, Chow L, Rozo V, Herman J, Still Brooks K, Colbath A, Hunter R, Dow S. PLoS One. 2020 Jun 25;15(6):e0235422. doi: 10.1371/journal.pone.0235422. PMID: 32584899; PMCID: PMC7316291.

Activated Mesenchymal Stromal Cell Therapy for Treatment of Multi-Drug Resistant Bacterial Infections in Dogs

Johnson V, Chow L, Harrison J, Soontararak S, Dow S. Front Vet Sci. 2022 Jun 23;9:925701. doi: 10.3389/fvets.2022.925701. PMID: 35812842; PMCID: PMC9260693.

more publications

People

Dr. Steven Dow headshot.
Steve Dow, D.V.M., Ph.D.

Principal Investigator

[email protected]

William Wheat, Ph.D.

Research Scientist II

Lyndah Chow Headshot
Lyndah Chow, Ph.D.

Research Scientist I

Jade Kurihara

Research Associate

Renata Impastato

Research Associate

Default Profile Picture of CSU Logo
Maggie Williams

Research Associate

Dylan Ammons headshot.
Dylan Ammons

Graduate Student

Jenna Cao headshot.
Jenna Cao

Graduate Student

Alison Manchester

Graduate Student

Lab rafting trip down the Poudre river.

Dow lab on their rafting trip before getting on the water.

Dow lab on a hiking trip.

news and updates view all

April 26, 2019 Man’s best friend: Translational Medicine Institute accelerates bench-to-bedside therapies for all species

A goofy poodle named Gus is making an immortal contribution to human and animal health. Gus belongs to Dr. Steve Dow and his wife, Robyn Elmslie, but stem cells from his skin will someday belong to the world.
October 12, 2018 Zoobiquity Colorado explores connections between human and animal health

Learn about Dr. Dow’s research to develop immunotherapy for kids & dogs with cancer.
February 23, 2018 Boris the polar bear, 32, receives stem cell treatment

Dr. Valerie Johnson gives Boris the Polar Bear an innovative stem cell treatment for his arthritis.

contact information

Offices:
Animal Cancer Center room B250
Translational Medicine Institute room 235

Laboratories:
Animal Cancer Center rooms B254, B260
Translational Medicine Institute rooms 235, 250

(970) 297-4014