The Akkina laboratory focuses on vaccination and antiviral therapy strategies for HIV intervention using rodent models. Ongoing studies involve developing high efficiency gene transfer methods including viral pseudotype and ribozyme expressing vectors. Dr. Akkina’s laboratory is funded by multiple NIH grants and other extramural sources and is unique in developing and utilizing SCID-hu and RAG mice as novel models in which to study HIV and Dengue virus intervention. This work has lead to new models to assess topical mucosally applied drugs to prevent sexually transmitted HIV infection.
research project
HIV Latency
400 Character (Including Spaces) Project Description Here
research project
HIV Evolution
400 Character (Including Spaces) Project Description Here
research project
HIV PrEP
400 Character (Including Spaces) Project Description Here
research project
HIV Gene Therapy
400 Character (Including Spaces) Project Description Here
Publications
A dual-purpose humanized mouse model for testing antiviral strategies against both SIV and HIV.
Barnett E, Kaginkar S, Schmitt K, Remling-Mulder L, Akkina R.Front Immunol. 2024 Nov 4;15:1491481. doi: 10.3389/fimmu.2024.1491481. eCollection 2024.PMID: 39559349
Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice.
Curlin JZ, Schmitt K, Remling-Mulder L, Tibbitts CV, O’Connor S, Marx P, Akkina R. J Med Primatol. 2023 Oct;52(5):294-297. doi: 10.1111/jmp.12675. Epub 2023 Sep 1.PMID: 37658595
Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice.
Curlin JZ, Schmitt K, Remling-Mulder L, Tibbitts CV, O’Connor S, Marx P, Akkina R. J Med Primatol. 2023 Oct;52(5):290-293. doi: 10.1111/jmp.12674. Epub 2023 Sep 1.PMID: 37658590
Zika virus induced microcephaly and aberrant hematopoietic cell differentiation modeled in novel neonatal humanized mice.
Schmitt K, Curlin JZ, Remling-Mulder L, Aboellail T, Akkina R. Front Immunol. 2023 Feb 7;14:1060959. doi: 10.3389/fimmu.2023.1060959. eCollection 2023. PMID: 36825016
Evolution of SIVmac239 following serial passaging in humanized mice.
Curlin JZ, Schmitt K, Remling-Mulder L, Morrison J, Baczenas JJ, Tibbits CV, Goff K, O’Connor S, Stenglein M, Marx P, Akkina R. J Med Primatol. 2022 Oct;51(5):284-287. doi: 10.1111/jmp.12614. Epub 2022 Aug 28. PMID: 36030392
more publications
contact information
Labs: Pathology room 305, 307
Office: Pathology room 329
(970) 491-1009
[email protected]
