Brain Research Center

The Brain Research Center is an interdisciplinary group of researchers and clinicians advancing brain research to better understand brain diseases in both animals and humans.

Mission

The Brain Research Center is composed of an interdisciplinary group of researchers and clinicians conducting state-of-the-art brain research. The Brain Research Center promotes this collaborative research network, supports undergraduate and graduate research and education, and, by leveraging this unified foundation of researchers, clinicians and associated infrastructure, strives to advance the field of brain research. The Brain Research Center seeks to promote and accelerate brain research, training and education, clinical proficiency, and environmental impact, which aligns with the strategic mission of Colorado State University.

Vision

The Brain Research Center is an interdisciplinary Center with the goal of conducting internationally recognized state-of-art research to advance the knowledge about brain aging, disease, and neurodegenerative processes. In assembling the Brain Research Center, we have selected members with diverse expertise, including neurodegeneration, molecular biology, mouse transgenesis, epidemiology, infectious disease, and clinical diseases, including aging, dementia, epilepsy, and cancer. The interdisciplinary approach is unique and essential to cultivate and strengthen brain research, both in veterinary medicine and in human medicine, using small and large animal models.

research project

Biomarker Research in Aging Dogs

research project

Glioma Vaccine Study

research project

Canine Comparative Biology Study

Collaboration with Children's Hospital of Philadelphia

research project

Cannabidiol in Canine Epilesy

Dose finding and safety of chronic administration of cannabidiol in dogs with intractable idiopathic epilepsy.

Publications

Targeting Neuroinflammation by Pharmacologic Downregulation of Inflammatory Pathways Is Neuroprotective in Protein Misfolding Disorders

Risen, S. J., Boland, S. W., Sharma, S., Weisman, G. M., Shirley, P. M., Latham, A. S., Hay, A. J. D., Gilberto, V. S., Hines, A. D., Brindley, S., Brown, J. M., McGrath, S., Chatterjee, A., Nagpal, P., & Moreno, J. A. (2024). ACS chemical neuroscience, 15(7), 1533–1547. https://doi.org/10.1021/acschemneuro.3c00846)

Long-term effect of oral cannabidiol administration to healthy adult dogs on tear production, intraocular pressure, and tear concentrations

Jost, H. E., Spitznagel, K., Alvarenga, I. C., Peraza, J., Banks, K., McGrath, S., & de Linde Henriksen, M. (2023). Veterinary ophthalmology, 10.1111/vop.13164. Advance online publication. https://doi.org/10.1111/vop.13164

Tolerability of long-term cannabidiol supplementation to healthy adult dogs

Corsato Alvarenga, I., Wilson, K. M., & McGrath, S. (2024). Journal of veterinary internal medicine, 38(1), 326–335. https://doi.org/10.1111/jvim.16949

Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline

Hines, A. D., McGrath, S., Latham, A. S., Kusick, B., Mulligan, L., Richards, M. L., & Moreno, J. A. (2023). Frontiers in aging neuroscience, 15, 1128521. https://doi.org/10.3389/fnagi.2023.1128521

Reprogramming the Canine Glioma Microenvironment with Tumor Vaccination plus Oral Losartan and Propranolol Induces Objective Responses

Ammons, D. T., Guth, A., Rozental, A. J., Kurihara, J., Marolf, A. J., Chow, L., Griffin, J. F., 4th, Makii, R., MacQuiddy, B., Boss, M. K., Regan, D. P., Frank, C., McGrath, S., Packer, R. A., & Dow, S. (2022). Cancer research communications, 2(12), 1657–1667. https://doi.org/10.1158/2767-9764.crc-22-0388

People

Dr. Stephanie McGrath

Director for the Brain Research Center

Office: (970) 491 - 7051

[email protected]

Dr. Julie Moreno

Associate Director for the Brain Research Center

Office: (970) 491 - 5410

[email protected]