The Brain Research Center is an interdisciplinary group of researchers and clinicians advancing brain research to better understand brain diseases in both animals and humans.
Mission
The Brain Research Center is composed of an interdisciplinary group of researchers and clinicians conducting state-of-the-art brain research. The Brain Research Center promotes this collaborative research network, supports undergraduate and graduate research and education, and, by leveraging this unified foundation of researchers, clinicians and associated infrastructure, strives to advance the field of brain research. The Brain Research Center seeks to promote and accelerate brain research, training and education, clinical proficiency, and environmental impact, which aligns with the strategic mission of Colorado State University.
Vision
The Brain Research Center is an interdisciplinary Center with the goal of conducting internationally recognized state-of-art research to advance the knowledge about brain aging, disease, and neurodegenerative processes. In assembling the Brain Research Center, we have selected members with diverse expertise, including neurodegeneration, molecular biology, mouse transgenesis, epidemiology, infectious disease, and clinical diseases, including aging, dementia, epilepsy, and cancer. The interdisciplinary approach is unique and essential to cultivate and strengthen brain research, both in veterinary medicine and in human medicine, using small and large animal models.
Clinical Trials
The Brain Research Center has a range of clinical trials.
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Publications
Targeting Neuroinflammation by Pharmacologic Downregulation of Inflammatory Pathways Is Neuroprotective in Protein Misfolding Disorders
Risen, S. J., Boland, S. W., Sharma, S., Weisman, G. M., Shirley, P. M., Latham, A. S., Hay, A. J. D., Gilberto, V. S., Hines, A. D., Brindley, S., Brown, J. M., McGrath, S., Chatterjee, A., Nagpal, P., & Moreno, J. A. (2024). ACS chemical neuroscience, 15(7), 1533–1547. https://doi.org/10.1021/acschemneuro.3c00846)
Long-term effect of oral cannabidiol administration to healthy adult dogs on tear production, intraocular pressure, and tear concentrations
Jost, H. E., Spitznagel, K., Alvarenga, I. C., Peraza, J., Banks, K., McGrath, S., & de Linde Henriksen, M. (2023). Veterinary ophthalmology, 10.1111/vop.13164. Advance online publication. https://doi.org/10.1111/vop.13164
Tolerability of long-term cannabidiol supplementation to healthy adult dogs
Corsato Alvarenga, I., Wilson, K. M., & McGrath, S. (2024). Journal of veterinary internal medicine, 38(1), 326–335. https://doi.org/10.1111/jvim.16949
Activated gliosis, accumulation of amyloid β, and hyperphosphorylation of tau in aging canines with and without cognitive decline
Hines, A. D., McGrath, S., Latham, A. S., Kusick, B., Mulligan, L., Richards, M. L., & Moreno, J. A. (2023). Frontiers in aging neuroscience, 15, 1128521. https://doi.org/10.3389/fnagi.2023.1128521
Reprogramming the Canine Glioma Microenvironment with Tumor Vaccination plus Oral Losartan and Propranolol Induces Objective Responses
Ammons, D. T., Guth, A., Rozental, A. J., Kurihara, J., Marolf, A. J., Chow, L., Griffin, J. F., 4th, Makii, R., MacQuiddy, B., Boss, M. K., Regan, D. P., Frank, C., McGrath, S., Packer, R. A., & Dow, S. (2022). Cancer research communications, 2(12), 1657–1667. https://doi.org/10.1158/2767-9764.crc-22-0388
