Background and Purpose of the Trial
Every year, about 3 out of 100 dogs are diagnosed with brain tumors. A common type of those belong to the glioma family of brain tumors – which are the toughest to treat due to their ability to escape traditional treatment methods that destroy non-glioma tumors.
This study is testing a chemotherapy drug that may be better at destroying glioma tumors than others – without the need for brain surgery.
Who Qualifies
- Dogs who are over 10kg (22lb) in body weight who have already had a brain tumor diagnosed on MRI.
- Dogs must be otherwise healthy with no other major diseases
- Dogs cannot have previously received chemotherapy or radiation for this tumor.
Study Design
Day 1
Visit 1
- Neurologic examination
- Blood draw for baseline bloodwork
- Begin verdinexor (chemo) therapy twice per week
Day 7
Visit 2
- Neurologic examination
- Blood draw for a complete blood cell count and chemistry profile
Day 21
Visit 3
- Neurologic examination
- Blood draw for a complete blood cell count and chemistry profile
Day 42
Visit 4
- Neurologic examination
- Blood draw for a complete blood cell count and chemistry profile
Month 3
Visit 5
- Neurologic examination
- Blood draw for a complete blood cell count and chemistry profile
- Brain MRI to evaluate tumor’s response
Month 6
Visit 6
- Neurologic examination
- Blood draw for a complete blood cell count and chemistry profile
- Brain MRI to evaluate tumor’s response
Study Cost
The pet owner will only need to make a one-time payment of $700.00 at enrollment to cover the cost of chemotherapy. Examinations, bloodwork, and recheck MRIs are sponsored by the study.