Braunstein Lab

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research project

In vivo assessment and optimization of phage PK/PD for the treatment of pulmonary Mycobacterium abscessus infection

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research project

A novel protein export chaperone of Mycobacterium tuberculosis

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Publications

Bacteriophage infection and killing of intracellular Mycobacterium abscessus.
Schmalstig AA, Wiggins A, Badillo D, Wetzel KS, Hatfull GF, Braunstein MmBio2024 Jan 16;15(1):e0292423doi: 10.1128/mbio.02924-23. Epub 2023 Dec 7. PubMed PMID: 38059609; PubMed Central PMCID: PMC10790704.

Pharmacokinetic Considerations for Optimizing Inhaled Spray-Dried Pyrazinoic Acid Formulations. 
Yeshwante SB, Hanafin P, Miller BK, Rank L, Murcia S, Xander C, Annis A, Baxter VK, Anderson EJ, Jermain B, Konicki R, Schmalstig AA, Stewart I, Braunstein M, Hickey AJ, Rao GG.
Mol Pharm2023 Sep 4;20(9):4491-4504doi: 10.1021/acs.molpharmaceut.3c00199. Epub 2023 Aug 17. PubMed PMID: 37590399; PubMed Central PMCID: PMC10868345.

Characterization of spectinamide 1599 efficacy against different mycobacterial phenotypes.
Temrikar ZH, Kodidela S, Kumar S, Liu J, Robertson GT, Lee RE, Hickey AJ, Gonzalez-Juarrero M, Meibohm B. Tuberculosis (Edinb)2023 May;140:102342doi: 10.1016/j.tube.2023.102342. Epub 2023 Apr 20. PubMed PMID: 37120915; PubMed Central PMCID: PMC10247484.

The Mfd protein is the transcription-repair coupling factor (TRCF) in Mycobacterium smegmatis.
Adebali O, Yang Y, Neupane P, Dike NI, Boltz JL, Kose C, Braunstein M, Selby CP, Sancar A, Lindsey-Boltz LA. J Biol Chem2023 Mar;299(3):103009doi: 10.1016/j.jbc.2023.103009. Epub 2023 Feb 11. PubMed PMID: 36775124; PubMed Central PMCID: PMC10023983.

A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis.
Kim M, Johnson CE, Schmalstig AA, Annis A, Wessel SE, Van Horn B, Schauer A, Exner AA, Stout JE, Wahl A, Braunstein M, Victor Garcia J, Kovarova M. Nat Commun. 2022 Aug 8;13(1):4455. doi: 10.1038/s41467-022-32043-3. PMID: 35941109

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People

Miriam Braunstein, Ph.D.

Principal Investigator [PI]
Professor

Marina Forrellad, Ph.D.

Postdoctoral Fellow

Andrew Wiggins, Ph.D.

Postdoctoral Fellow

Fabiana Bisaro

Postdoctoral Fellow

Anne Chenchar

Research Associate II

Andrea Russell

Graduate Research Assistant

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You can include a slideshow (up to five slides) of whatever additional content the lab would like. Like the other slideshow block, use horizontal images and short descriptions.

You can include a slideshow (up to five slides) of whatever additional content the lab would like. Like the other slideshow block, use horizontal images and short descriptions.

contact information

Office: Microbiology C230

Laboratories:
Laboratory location goes here

(970) 491-0093