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Henao Tamayo Lab

Our laboratory is dedicated to investigating the pathogenesis and immune response to mycobacterial species, specifically M. tuberculosis, M. avium, and M. abscessus, with a primary focus on the immune responses triggered by the infection and with a particular interest in developing and testing vaccines.

In our laboratory, through a team science approach, we aim to improve vaccine regimens and approaches, incorporating environmental parameters, age, and sex differences known to alter the immune response. To investigate the host-pathogen interactions, we use multiparametric and transcriptional (single-cell RNA sequencing and spatial transcriptomics) unbiased analysis of the cells induced after vaccination and infection. We also utilize metabolomics, proteomics and multiple technologies to evaluate mycobacterial replication compounded with data science and modeling to search for biomarkers of protection against disease.

research project

Immune Mechanisms of Protection Against Mycobacterium tuberculosis Center (IMPAC-TB)

The Henao Tamayo and Podell labs are leading a CSU team on a $1.2 million subcontract to accelerate research progress in tuberculosis vaccines. Objectives are to understand the immune responses that prevents initial infection, the establishment of latent infection, and the transition to active TB disease. There is currently only one vaccine for TB and it only reliably works on children.

research project

Vaccine induced memory immunity in tuberculosis

There are several vaccine candidates that give protection against the laboratory strains H37Rv and Erdman at a level comparable to the BCG vaccine. However, whether different vaccine types give equivalent or different levels of memory T cell subsets is unknown, and whether these vaccines will be equally protective against newly emerging highly virulent clinical strains is equally unaddressed.

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Publications

A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides.
Zohaib Ali M, Dutt TS, MacNeill A, Walz A, Pearce C, Lam H, Philp JS, Patterson J, Henao-Tamayo M, Lee R, Liu J, Robertson GT, Hickey AJ, Meibohm B, Gonzalez Juarrero M. Elife. 2024 Oct 8;13:RP96190. doi: 10.7554/eLife.96190. PMID: 39378165

Heterogeneity in immune cell composition is associated with Mycobacterium tuberculosis replication at the granuloma level.
Cooper SK, Ackart DF, Lanni F, Henao-Tamayo M, Anderson GB, Podell BK. Front Immunol. 2024 Aug 26;15:1427472. doi: 10.3389/fimmu.2024.1427472. eCollection 2024. PMID: 39253081

A single-cell atlas of the Culex tarsalis midgut during West Nile virus infection.
Fitzmeyer EA, Dutt TS, Pinaud S, Graham B, Gallichotte EN, Hill JL, Campbell CL, Ogg H, Howick V, Lawniczak M, Nishimura EO, Merkling SH, Henao-Tamayo M, Ebel GD. bioRxiv [Preprint]. 2024 Aug 16:2024.07.23.603613. doi: 10.1101/2024.07.23.603613. PMID: 39091762

Discrimination of Jamaican fruit bat lymphocytes by flow cytometry.
Burke BE, Rocha SM, Campbell C, Creissen E, Tjalkens RB, Ma W, Henao-Tamayo M, Schountz T. bioRxiv [Preprint]. 2024 Jul 19:2024.07.18.604131. doi: 10.1101/2024.07.18.604131. PMID: 39071331

Deciphering bat influenza H18N11 infection dynamics in male Jamaican fruit bats on a single-cell level.
Kessler S, Burke B, Andrieux G, Schinköthe J, Hamberger L, Kacza J, Zhan S, Reasoner C, Dutt TS, Kaukab Osman M, Henao-Tamayo M, Staniek J, Villena Ossa JF, Frank DT, Ma W, Ulrich R, Cathomen T, Boerries M, Rizzi M, Beer M, Schwemmle M, Reuther P, Schountz T, Ciminski K.Nat Commun. 2024 May 27;15(1):4500. doi: 10.1038/s41467-024-48934-6.PMID: 38802391

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