Our laboratory, as part of the CSU Mycobacteria Research Laboratories, is dedicated to investigating the pathogenesis and immune response to mycobacterial species, specifically M. tuberculosis, M. avium, and M. abscessus, with a primary focus on the immune responses triggered by the infection and with a particular interest in developing and testing vaccines.
Through a team science approach, we aim to improve vaccine regimens and approaches, incorporating environmental parameters, age, and sex differences known to alter the immune response. To investigate the host-pathogen interactions, we use multiparametric and transcriptional (single-cell RNA sequencing and spatial transcriptomics) unbiased analysis of the cells induced after vaccination and infection. We also utilize metabolomics, proteomics and multiple technologies to evaluate mycobacterial replication compounded with data science and modeling to search for biomarkers of protection against disease.
People
Lab Principal Investigator [PI]
Associate Department Head for Undergraduate Education
Associate Professor
Director, CSU Flow Cytometry Facility
Student Researcher
news and updates view all
Karen Dobos and Marcela Henao-Tamayo talk with President Amy Parsons on her podcast about How CSU is Tackling Tuberculosis.
The Conversation asked microbiologists Marcela Henao-Tamayo and Karen Dobos, both from Colorado State University, to explain why this ancient disease seems to be making a comeback.
Henao-Tamayo Lab’s Elizabeth Dorst wins College Honors for her work on tuberculosis meningitis in mice at the CURC showcase.
contact information
Lab: Microbiology room C210
Office: Microbiology room C221
(970) 491-5357
[email protected]