The Jackson laboratory, as part of the Mycobacteria Research Laboratories and NTM Basic and Translational Research Center, investigates the structure, biosynthesis and transport of cell envelope lipids and (lipo)polysaccharides playing important roles in the physiology and pathogenicity of mycobacteria.
Our laboratory also studies Mycobacterium leprae and emerging non-tuberculous mycobacterial pathogens, the strategies used by these organisms to persist in the environment, and their molecular mechanisms of pathogenicity and resistance to biocides.
Another aspect of our research concerns the development of anti-mycobacterial drugs and the study of their mechanism of action.
Publications
Cell envelope polysaccharide modifications alter the surface properties and interactions of Mycobacterium abscessus with innate immune cells in a morphotype-dependent manner
Lian E, Belardinelli JM, De K, Pandurangan AP, Angala SK, Palčeková Z, Grzegorzewicz AE, Bryant JM, Blundell TL, Parkhill J, Floto RA, Wheat WH, Jackson M. . mBio. 2025 Mar 14;:e0032225. doi: 10.1128/mbio.00322-25. [Epub ahead of print] PubMed PMID: 40084888.
The DosR regulon of Mycobacterium avium and adaptation to hypoxia
Belardinelli JM, Avanzi C, Martin KE, Lam H, Dragset MS, Wheat WH, Podell BK, Gonzalez-Juarrero M, Jackson M.. Front Cell Infect Microbiol. 2025;15:1545856. doi: 10.3389/fcimb.2025.1545856. eCollection 2025. PubMed PMID: 40041152; PubMed Central PMCID: PMC11876180.
Mycobacterium leprae in Nine-Banded Armadillos (Dasypus novemcinctus), Ecuador
Romero-Alvarez D, Calvopiña M, Cisneros-Vásquez E, Garzon-Chavez D, Warren AK, Bennett LS, Janapati RR, Bastidas-Caldes C, Cabezas-Moreno M, de Waard JH, Silva-Martinod D, Schaub R, Jackson M, Peterson AT, Avanzi C. . Emerg Infect Dis. 2024 Dec;30(12):2629-2632. doi: 10.3201/eid3012.231143. PubMed PMID: 39592404; PubMed Central PMCID: PMC11616649.
Mycobacterium abscessus pulmonary infection and associated respiratory function in cystic fibrosis-like βENaC mice.
Pearce CM, Shaw TD, Podell B, Jackson M, Henao-Tamayo M, Obregon-Henao A, Lam H, Alshiraihi IM, O’Neal W, Livraghi-Butrico A, Hickey AJ, Meibohm B, Gonzalez-Juarrero M. Front Tuberc. 2024;2. doi: 10.3389/ftubr.2024.1473341. Epub 2024 Oct 30. PubMed PMID: 39950136; PubMed Central PMCID: PMC11822858.
Allosteric coupling of substrate binding and proton translocation in MmpL3 transporter from Mycobacterium tuberculosis
Babii S, Li W, Yang L, Grzegorzewicz AE, Jackson M, Gumbart JC, Zgurskaya HI.. mBio. 2024 Oct 16;15(10):e0218324. doi: 10.1128/mbio.02183-24. Epub 2024 Aug 30. PubMed PMID: 39212407; PubMed Central PMCID: PMC11481577.
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