The Jackson laboratory, as part of the Mycobacteria Research Laboratories and NTM Basic and Translational Research Center, investigates the structure, biosynthesis and transport of cell envelope lipids and (lipo)polysaccharides playing important roles in the physiology and pathogenicity of mycobacteria.
Our laboratory also studies Mycobacterium leprae and emerging non-tuberculous mycobacterial pathogens, the strategies used by these organisms to persist in the environment, and their molecular mechanisms of pathogenicity and resistance to biocides.
Another aspect of our research concerns the development of anti-mycobacterial drugs and the study of their mechanism of action.
Publications
Next-generation rifamycins for the treatment of mycobacterial infections.
Dartois V, Lan T, Ganapathy US, Wong CF, Sarathy JP, Jimenez DC, Alshiraihi IM, Lam H, Rodriguez S, Xie M, Soto-Ojeda M, Jackson M, Wheat W, Dillman NC, Kostenkova K, Schmitt J, Mann L, Richter A, Imming P, Sarathy J, Kaya F, Paruchuri S, Tatek B, Folvar C, Proietto J, Zimmerman M, Gonzalez-Juarrero M, Aldrich CC, Dick T. Proc Natl Acad Sci U S A. 2025 May 6;122(18):e2423842122. doi: 10.1073/pnas.2423842122. Epub 2025 May 1. PMID: 40310456
C3HeB/FeJ mice with chronic Mycobacterium avium complex pulmonary infection exhibit impaired respiratory function but not necrotising granulomatous disease.
Shaw TD, Pearce CM, Lam H, Alshiraihi IM, Dutt T, Obregon-Henao A, Henao-Tamayo M, Jackson M, Gonzalez-Juarrero M. Mycobacteria. 2025;1(1):4. doi: 10.1186/s44350-025-00004-7. Epub 2025 May 15. PMID: 40386578
The DosR regulon of Mycobacterium avium and adaptation to hypoxia.
Belardinelli JM, Avanzi C, Martin KE, Lam H, Dragset MS, Wheat WH, Podell BK, Gonzalez-Juarrero M, Jackson M. Front Cell Infect Microbiol. 2025 Feb 18;15:1545856. doi: 10.3389/fcimb.2025.1545856. eCollection 2025. PMID: 40041152
Cell envelope polysaccharide modifications alter the surface properties and interactions of Mycobacterium abscessus with innate immune cells in a morphotype-dependent manner
Lian E, Belardinelli JM, De K, Pandurangan AP, Angala SK, Palčeková Z, Grzegorzewicz AE, Bryant JM, Blundell TL, Parkhill J, Floto RA, Wheat WH, Jackson M. . mBio. 2025 Mar 14;:e0032225. doi: 10.1128/mbio.00322-25. [Epub ahead of print] PubMed PMID: 40084888.
Mycobacterium leprae in Nine-Banded Armadillos (Dasypus novemcinctus), Ecuador
Romero-Alvarez D, Calvopiña M, Cisneros-Vásquez E, Garzon-Chavez D, Warren AK, Bennett LS, Janapati RR, Bastidas-Caldes C, Cabezas-Moreno M, de Waard JH, Silva-Martinod D, Schaub R, Jackson M, Peterson AT, Avanzi C. . Emerg Infect Dis. 2024 Dec;30(12):2629-2632. doi: 10.3201/eid3012.231143. PubMed PMID: 39592404; PubMed Central PMCID: PMC11616649.
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