Our lab, of the Center for Vector-Borne Infectious Diseases (CVID), studies the ecology and transmission dynamics of vector-borne pathogens, particularly emerging arboviruses. A multitude of factors influence the enzootic circulation of arboviruses and their potential for introduction and establishment in new geographic areas. We are interested in understanding the natural, sylvatic circulation of arboviruses in endemic areas, how an arbovirus might become established in vector and host populations in new geographic areas, and entomological risk factors surrounding such introductions.
To this end, our field and laboratory studies are focused on evaluation of the biological capacity of different mosquito species and populations to support virus replication and serve as efficient vectors, potential mechanisms for virus maintenance in mosquito populations, and the how the interactions of a mosquito species with competent vertebrate amplifying hosts over space and time may influence epizootic virus activity. In addition to these entomological studies, we have an ongoing project to investigate the potential role of bats as arbovirus reservoirs and a source of emerging arboviruses.
Potential of North American mosquitoes to transmit and maintain Rift Valley fever virus (RVFV)
Ecology, Epidemiology, and Biosurveillance for emerging viral pathogens of Ugandan bats
Surveillance of Mosquito and Arbovirus Dispersal Using Smart Microcrystals
Transstadial inhibition of Rift Valley Fever virus infection in Ae. aegypti mosquitoes
Exploring the Mosquito-Arbovirus Network: A Survey of Vector Competence Experiments.
Am J Trop Med Hyg. 2023 Apr 10;108(5):987-994. doi: 10.4269/ajtmh.22-0511. Print 2023 May 3. PMID: 37037424
Scalable Combinatorial Assembly of Synthetic DNA for Tracking Applications.
Int J Mol Sci. 2023 Jan 29;24(3):2549. doi: 10.3390/ijms24032549. PMID: 36768872
Mosquito tagging using DNA-barcoded nanoporous protein microcrystals.
PNAS Nexus. 2022 Sep 12;1(4):pgac190. doi: 10.1093/pnasnexus/pgac190. eCollection 2022 Sep. PMID: 36714845
Exposure of Egyptian Rousette Bats (Rousettus aegyptiacus) and a Little Free-Tailed Bat (Chaerephon pumilus) to Alphaviruses in Uganda.
Diseases. 2022 Dec 5;10(4):121. doi: 10.3390/diseases10040121. PMID: 36547207
A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection.
Front Immunol. 2022 Feb 16;13:811430. doi: 10.3389/fimmu.2022.811430. eCollection 2022. PMID: 35250984
news and updates
The Kading Lab and Department of Chemical and Biological Engineering colleagues have developed a unique method to track disease-carrying mosquitoes.
Natalie Wickenkamp, a graduate student in the Kading Lab, won the Innovation in Veterinary Medicine and Biomedical Sciences Award at CSU’s Demo Day.
Olivia Martinez, one of four MARC scholars, joins Kading Lab in studying the ecology and transmission dynamics of vector-borne pathogens.