The McCosh lab investigates the neural regulation of reproduction. Specifically, we have projects investigating mechanisms by which luteinizing hormone pulses are generated and how these pulses are inhibited during stress. We are also interested in the neural pathways responsible for generating the preovulatory luteinizing hormone surge (the signal for ovulation). We employ a variety of integrative and molecular techniques in sheep, mice, and cell culture models to study kisspeptin neurons and how they are regulated.
Suppression of gonadotropin secretion in stress
Luteinizing hormone (LH) is released in a pulsatile pattern to regulate gonad function. During stress, the secretion of this important hormone is inhibited. We are investigating the neural mechanisms for this process.
Generation of the preovulatory LH surge
Ovulation is induced by surge-type secretion of Luteinizing Hormone in females. We are investigating the neural pathways responsible for orchestrating this pattern of LH release in mice and sheep.
Chronic stress and fertility
Persistent, long-term exposure to stress is associated with impaired gonadotropin secretion and infertility in humans. We are investigating neural pathways for impaired reproductive function during chronic stress in mouse models.
Main Campus Office: Anatomy/Zoology Building, Room E306
Main Campus Laboratory: Anatomy/Zoology Building, Room E314
Foothills Campus Office: Animal Reproduction and Biotechnology Laboratory Building, Room W117
Foothills Campus Laboratory: Animal Reproduction and Biotechnology Laboratory Building, Room W100