The Myers Lab focuses on the integration of limbic neurocircuits to determine the biological basis for stress effects on health. Specifically, we combine behavioral neuroscience and integrative physiology to examine how the brain mediates relationships between mood/anxiety disorders and cardiometabolic conditions.
Experiments utilize viral-mediated gene transfer in rodent models to monitor and modulate the activity of specific cells, circuits, and synapses. These approaches allow us to measure social, affective, and motivational behaviors, as well as endocrine and cardiovascular physiology.
Wallace T, Schaeuble D, Pace SA, Schackmuth MK, Hentges ST, Chicco AJ, Myers B. Sexually divergent cortical control of affective-autonomic integration. Psychoneuroendocrinology 129 (105238), 2021.
Pace SA, Christensen C, Schackmuth MK, Wallace T, McKlveen JM, Beischel W, Morano RL, Scheimann JR, Wilson SP, Herman JP, Myers B. Reduced glutamate outflow from infralimbic prefrontal cortex prevents the neural and behavioral consequences of chronic stress. Neurobiol. Stress 13 (1002742), 2020.
Schaeuble D, Packard AEB, McKlveen JM, Morano R, Fourman S, Smith BL, Scheimann JR, Packard BA, Wilson SP, James J, Hui DY, Ulrich-Lai YU, Herman JP, Myers B. Prefrontal cortical regulation of chronic stress-induced cardiovascular susceptibility. J. Am. Heart Assoc. 8:24 (e014451), 2019.
McKlveen JM, Moloney RD, Scheimann JR, Myers B, Herman JP. Braking the prefrontal cortex: the role of glucocorticoids and interneurons in stress adaptation and pathology. Biol. Psychiatry 86:9 (669-681), 2019.
Wood M, Adil O, Wallace T, Fourman S, Wilson SP, Herman JP, Myers B. Infralimbic prefrontal cortical structural and functional connectivity with the limbic forebrain: a combined viral genetic and optogenetic analysis. Brain Struct. Funct. 224:1 (73-97), 2019.more publications
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Brent Myers, Ph.D.
Department of Biomedical Sciences
Colorado State University
1617 Campus Delivery
Fort Collins, CO 80523