Goodrich Lab – Faculty Research – College of Veterinary Medicine and Biomedical Sciences

Goodrich Lab

The Goodrich Lab research projects are focused on treating and preventing disease transmission. This includes research on methods to prevent transfusion transmitted diseases by using photochemical methods to inactivate bacteria, viruses and parasites that may be transmitted in donated blood products. The work in the Goodrich Lab and through collaborations with other investigators has led to the development of several vaccine candidates for diseases including SARS-CoV-2, Tuberculosis, Human and Avian Influenza and African Swine Fever, using a technology platform for production of vaccines and treatment of blood products invented in collaboration with colleagues at Colorado State University.

research project

Production and Testing of SARS-CoV-2 Vaccine

Manufacturing of a vaccine for COVID-19 using the SolaVAX technology platform. This work includes developing GMP manufacturing and characterization of immune response in animal models.

research project

Development of a vaccine for human influenza

Testing of adjuvant formulations in mouse and ferret animal models. Characterization of immunological response and protection from live challenge.

research project

Development of a vaccine for Avian influenza

Testing of adjuvant formulations and delivery routes in poultry. This work focuses on oral and mucosal routes of delivery.

research project

Development of a vaccine for African Swine Fever

Includes an attenuated virus and adjuvant formulations intended to promote cellular immune responses. This work includes evaluation of immunological response and protection against challenge with live virus.

research project

Development of Photochemical Devices for pathogen inactivation of blood products and large scale manufacturing of vaccine formulations

Prototyping and development of devices and disposables that allow for large scale treatment of blood and biological solutions. Applications include treatment of blood products for transfusion and vaccine batches for large volume production.

Publications

Kaposi’s sarcoma herpesvirus seroprevalence among blood donors in Uganda
Huso T, White JL, Kyeyune D, D’Adamo A, Labo N, Miley W, et al. Transfusion. 2025. https://doi.org/10.1111/trf.18236

Emerging Pathogen Threats in Transfusion Medicine: Improving Safety and Confidence with Pathogen Reduction Technologies
Cardoso M, Ragan I, Hartson L, Goodrich RP. Pathogens. 2023 Jul 5;12(7):911. doi: 10.3390/pathogens12070911. PMID: 37513758

SARS-CoV-2 seroprevalence among blood donors in Uganda: 2019-2022.
Bloch EM, Kyeyune D, White JL, Ddungu H, Ashokkumar S, Habtehyimer F, Baker O, Kasirye R, Patel EU, Grabowski MK, Musisi E, Moses K, Hume HA, Lubega I, Shrestha R, Motevalli M, Fernandez RE, Reynolds SJ, Redd AD, Wambongo Musana H, Dhabangi A, Ouma J, Eroju P, de Lange T, Fowler MG, Musoke P, Stramer SL, Whitby D, Zimmerman PA, McCullough J, Sachithanandham J, Pekosz A, Goodrich R, Quinn TC, Ness PM, Laeyendecker O, Tobian AAR. Transfusion. 2023 Jul;63(7):1354-1365. doi: 10.1111/trf.17449. Epub 2023 Jun 16. PMID: 37255467

Pathogen reduction of monkeypox virus in plasma and whole blood using riboflavin and UV light.
Izabela K Ragan, Lindsay M Hartson, Elizabeth J Sullivan, Richard A Bowen, Raymond P Goodrich (2023) PLoS One 18 (1), e0278862

The Mirasol Evaluation of Reduction in Infections Trial (MERIT) : study protocol for a randomized controlled clinical trial.
Aaron Tobian; Ronnnie Kasirye; Heather Hume; Evan Bloch; Irene Lubega; Dorothy Kyeyune; Ruchee Shrestha; Henry Ddungu; Hellen Wambongo Musana; Aggrey Dhabangi; Joseph Ouma; Priscilla Eroju; Telsa de Lange; Michael Tartakovsky; Jodie White; Ceasar Kakura; Mary Glenn Fowler; Philippa Musoke; Monica Nolan; Kate Grabowski; Lawrence Moulton; Susan Stramer; Denise Whitby; Peter Zimmerman; Deo Wabwire; Isaac Kajja; Jeffrey McCullough; Raymond Goodrich; Thomas Quinn; Robert Cortes; Paul Ness (2022) 23(1): 1-13.

more publications