Sones Lab

The Sones laboratory at the CSU Equine Reproduction Laboratory focuses on the basic mechanisms of pregnancy. The interaction of the microbiome, inflammation, and pre-existing conditions, such as obesity, impact fertility. Our studies seek to improve reproductive success of both the mare and stallion.

research project

Effects of maternal obesity on oocyte aging in female offspring of the BPH/5 preeclamptic-like mouse

This project seeks to characterize the transgeneration impact of obesity on oocyte development in a murine model.

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research project

Mechanisms of maternal obesity and feto-placental development in preeclampsia

This project seeks to test the hypothesis that pro-inflammatory mediators produced by maternal adipose tissue (leptin) reduce pro-angiogenic immune cells and factors at the maternal-fetal interface.

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research project

Microbiome of Small Ruminants in a Breeding Program

This project seeks to describe the association of the oronasal, fecal, and vaginal microbiome on fertility in ewes and does bred by artificial insemination.

research project

A large animal model of preexisting obesity as a contributing factor to impaired placental development

This project seeks to determine the influence of maternal leptin on early placental development in normal and obese mares.

Publications

Estrogen and Progesterone Receptors are Dysregulation at the BPH/5 Mouse Preeclamptic-like Materanl-Fetal Interface.
Biology vol. 13,3 192. 16 Mar. 2024, doi:10.3390/biology13030192

Effect of Sampling Method on Detection of the Equine Uterine Microbiome during Estrus
Veterinary sciences vol. 10,11 644. 8 Nov. 2023, doi:10.3390/vetsci10110644

Reversal of maternal obesity attenuates hypoxia and improves placental development in the preeclamptic-like BPH/5 mouse model
Biocell: official journal of the Sociedades Latinoamericanas de Microscopia Electronica … et. al vol. 47,9 (2023): 2051-2058. doi:10.32604/biocell.2023.029644

Metagenetic Analysis of the Pregnant Microbiome in Horses
Animals: an open access journal from MDPI vol. 13,12 1999. 15 Jun. 2023, doi:10.3390/ani13121999

Effects of fenbendazole on fecal microbiome in BPH/5 mice, a model of hypertension and obesity, a brief report.
PloS one vol. 18,6 e0287145. 9 Jun. 2023, doi:10.1371/journal.pone.0287145

more publications

People

Jenny Sones, D.V.M., Ph.D., Dipl. ACT

Principal Investigator

[email protected]

Nicole Bartz

[email protected]

Sophie Downing

[email protected]

Julie Wall
Patricio Razquin, D.V.M.

[email protected]

Javier Funes, D.V.M.

[email protected]

news and updates view all

September 9, 2024 $3 Million National Institutes of Health (NIH) R01 Grant Award

Congratulations to Dr. Jenny Sones and the Sones laboratory on her $3 million National Institutes of Health (NIH) R01 grant award! This grant will allow us to research how maternal obesity with hyperphagia contributes to the risk of preeclampsia, pregnancy hypertension, and cardiometabolic disease in offspring. The Sones laboratory focuses on the basic mechanisms of pregnancy. […]