Inhibition of Biofilm Formation

A collaborative team of MIP researchers discovered that amoebae have the ability to disrupt MRSA and Mycobacterium bovis biofilms.

As part of a Defense Advanced Research Projects Agency (DARPA) funded project, researchers from the Borlee laboratory teamed up with Mary Jackson and William Wheat of the CSU Mycobacteria Research Laboratories to destroy biofilms produced by MRSA and M. bovis using amoebae and the molecules secreted by amoebae.


The video shows Acanthamoeba polyphaga boring channels through a MRSA biofilm. The MRSA biofilm is visualized by the production of GFP (green fluorescent protein) using confocal microscopy.