The Dean lab has a major focus on the development of a probiotic vaccine platform utilizing the probiotic organism Lactobacillus acidophilus. Specific applications include vaccines against human rotavirus, feline coronavirus (FECV) and SARS-CoV-2. We study the host mucosal immune response and immune mechanisms of multiple adjuvant strategies. The relationship between the host microbiome and mucosal immunity and the impact of oral vaccination on the intestinal microbiome are also active areas of research. Study of the immunpathogenesis of viral infections is an overarching emphasis.
Vaccine Development Against SARS-CoV-2
Human Rotavirus Vaccine Development
Investigating the Relationship Between Recombinant Lactobacillus acidophilus and the Local Bacterial Microbiome
Vaccine Development for the Prevention of Feline Infectious Peritonitis Virus (FIP)
Improvements in Feline Infectious Peritonitis Virus (FIP) Diagnostics
Impact of oral probiotic Lactobacillus acidophilus vaccine strains on the immune response and gut microbiome of mice.
Abdo Z, LeCureux J, LaVoy A, Eklund B, Ryan EP, Dean GA.
PLoS One. 2019 Dec 12;14(12):e0225842. doi: 10.1371/journal.pone.0225842. eCollection 2019.
Effects of Regulatory T Cell Depletion on NK Cell Responses against Listeria monocytogenes in Feline Immunodeficiency Virus Infected Cats.
Simões RD, LaVoy A, Dean GA.
Viruses. 2019 Oct 24;11(11). pii: E984. doi: 10.3390/v11110984.
Vilander AC, Dean GA.
Vaccines (Basel). 2019 Oct 16;7(4). pii: E150. doi: 10.3390/vaccines7040150. Review.
Pearson M, LaVoy A, Evans S, Vilander A, Webb C, Graham B, Musselman E, LeCureux J, VandeWoude S, Dean GA.
Viruses. 2019 Sep 27;11(10). pii: E906. doi: 10.3390/v11100906.
LeCureux JS, Dean GA.
mSphere. 2018 May 16;3(3). pii: e00061-18. doi: 10.1128/mSphere.00061-18. eCollection 2018 May-Jun. Review.
Lab Principal Investigator (PI)
Department Head & Professor
Research Associate IV
Anatomic Pathology Resident
news and updates
The Dean lab is developing a vaccine for COVID-19 using a bacteria found in yogurt.
A bacteria found in yogurt shows promise for a COVID-19 vaccine.
The Dean lab switched from studying human rotavirus to finding a vaccine for COVID-19.