The Dean lab of the Center for Vector-Borne Infectious Diseases has a major focus on the development of a probiotic vaccine platform utilizing the probiotic organism Lactobacillus acidophilus. Specific applications include vaccines against human rotavirus, feline coronavirus (FECV) and SARS-CoV-2. We study the host mucosal immune response and immune mechanisms of multiple adjuvant strategies. The relationship between the host microbiome and mucosal immunity and the impact of oral vaccination on the intestinal microbiome are also active areas of research. Study of the immunpathogenesis of viral infections is an overarching emphasis.
research project
Vaccine Development Against SARS-CoV-2
view project
research project
Human Rotavirus Vaccine Development
view project
research project
Investigating the Relationship Between Recombinant Lactobacillus acidophilus and the Local Bacterial Microbiome
view project
research project
Vaccine Development for the Prevention of Feline Infectious Peritonitis Virus (FIP)
view project
research project
Improvements in Feline Infectious Peritonitis Virus (FIP) Diagnostics
view project
Publications
Lactobacillus acidophilus Expressing Murine Rotavirus VP8 and Mucosal Adjuvants Induce Virus-Specific Immune Responses.
Gilfillan D, Vilander AC, Pan M, Goh YJ, O’Flaherty S, Feng N, Fox BE, Lang C, Greenberg HB, Abdo Z, Barrangou R, Dean GA. Vaccines (Basel). 2023 Nov 28;11(12):1774. doi: 10.3390/vaccines11121774. PMID: 38140179
Review: The PI3K-AKT-mTOR signal transduction pathway in canine cancer.
Meuten TK, Dean GA, Thamm DH.Vet Pathol. 2023 Oct 31:3009858231207021. doi: 10.1177/03009858231207021. Online ahead of print. PMID: 37905509
Expression of E. coli FimH Enhances Trafficking of an Orally Delivered Lactobacillus acidophilus Vaccine to Immune Inductive Sites via Antigen-Presenting Cells.
Vilander AC, Shelton K, LaVoy A, Dean GA. Vaccines (Basel). 2023 Jun 27;11(7):1162. doi: 10.3390/vaccines11071162. PMID: 37514978
Oral Vaccination Using a Probiotic Vaccine Platform Combined with Prebiotics Impacts Immune Response and the Microbiome.
Fox BE, Vilander AC, Gilfillan D, Dean GA, Abdo Z.Vaccines (Basel). 2022 Sep 4;10(9):1465. doi: 10.3390/vaccines10091465. PMID: 36146543
NOD2 signaling in CD11c + cells is critical for humoral immune responses during oral vaccination and maintaining the gut microbiome.
Fox BE, Vilander A, Abdo Z, Dean GA. Sci Rep. 2022 May 19;12(1):8491. doi: 10.1038/s41598-022-12469-x. PMID: 35589853
more publications
news and updates
view all
November 12, 2024
Morris Animal Foundation and EveryCat Health Foundation Join Forces to Fight Deadly Disease
An international consortium of researchers, led by Dr. Gregg Dean, are collaborating on a program to diagnose, treat and prevent a new form of feline infectious peritonitis in Cyprus.
July 30, 2024
CSU student selected as 2024 Astronaut Scholar
Sophie Kiehl, an Honors Program student in the Dean & Vilander lab, was selected as a 2024 Astronaut Scholar. The scholarship is awarded to exceptional STEM majors with documented contributions to their fields, who wish to pursue research or further their field.
April 24, 2024
CSU student named prestigious Goldwater Scholar
Paris Kiehl, an Honors Program student in the Dean and Vilander lab, earns the prestigious Goldwater Scholarship Award for demonstrating research excellence and leadership.
contact information
Lab: Center for Vector-Borne Infectious Diseases room 130
Office: Center for Vector-Borne Infectious Diseases room 166
(970) 492-4368
[email protected]