Dean Lab

The Dean lab has a major focus on the development of a probiotic vaccine platform utilizing the probiotic organism Lactobacillus acidophilus. Specific applications include vaccines against human rotavirus, feline coronavirus (FECV) and SARS-CoV-2. We study the host mucosal immune response and immune mechanisms of multiple adjuvant strategies. The relationship between the host microbiome and mucosal immunity and the impact of oral vaccination on the intestinal microbiome are also active areas of research. Study of the immunpathogenesis of viral infections is an overarching emphasis.

research project

Vaccine Development Against SARS-CoV-2

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research project

Investigating the Relationship Between Recombinant Lactobacillus acidophilus and the Local Bacterial Microbiome

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research project

Vaccine Development for the Prevention of Feline Infectious Peritonitis Virus (FIP)

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research project

Improvements in Feline Infectious Peritonitis Virus (FIP) Diagnostics

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Publications

Impact of oral probiotic Lactobacillus acidophilus vaccine strains on the immune response and gut microbiome of mice.

Abdo Z, LeCureux J, LaVoy A, Eklund B, Ryan EP, Dean GA.
PLoS One. 2019 Dec 12;14(12):e0225842. doi: 10.1371/journal.pone.0225842. eCollection 2019.

Effects of Regulatory T Cell Depletion on NK Cell Responses against Listeria monocytogenes in Feline Immunodeficiency Virus Infected Cats.

Simões RD, LaVoy A, Dean GA.
Viruses. 2019 Oct 24;11(11). pii: E984. doi: 10.3390/v11110984.

Adjuvant Strategies for Lactic Acid Bacterial Mucosal Vaccines.

Vilander AC, Dean GA.
Vaccines (Basel). 2019 Oct 16;7(4). pii: E150. doi: 10.3390/vaccines7040150. Review.

Mucosal Immune Response to Feline Enteric Coronavirus Infection.

Pearson M, LaVoy A, Evans S, Vilander A, Webb C, Graham B, Musselman E, LeCureux J, VandeWoude S, Dean GA.
Viruses. 2019 Sep 27;11(10). pii: E906. doi: 10.3390/v11100906.

Lactobacillus Mucosal Vaccine Vectors: Immune Responses against Bacterial and Viral Antigens.

LeCureux JS, Dean GA.
mSphere. 2018 May 16;3(3). pii: e00061-18. doi: 10.1128/mSphere.00061-18. eCollection 2018 May-Jun. Review.

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People

Gregg Dean, DVM, PhD

Lab Principal Investigator (PI)
Department Head & Professor

Allison Vilander, DVM, PhD

Assistant Professor
Anatomic Pathologist

Alora LaVoy

Research Associate IV
Lab Manager

Ben Curtis, DVM

Anatomic Pathology Resident
PhD Candidate

Bridget Eklund

PhD Candidate

Darby Gilfillan

PhD Candidate

Maxwell Drummond

Research Assistant

Brianna Ramirez Rubio

Student Researcher

Kimberly Shelton

Student Researcher

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