Ebel Lab

Infections transmitted by arthropods such as mosquitoes and ticks represent some of the most difficult and persistent problems facing public health and medicine. The Ebel Lab, as part of the CSU Center for Vector-borne Infectious Diseases, is mainly interested in arthropod-borne viruses (arboviruses), such as West Nile, dengue, and Zika viruses. We exist to help find ways to make these types of infections less burdensome. Our research addresses several areas, including arbovirus population biology and evolution, mechanisms that permit mosquitoes to transmit arboviruses, mosquito immunity, and disease surveillance. Our currently funded projects focus on West Nile, dengue, Zika and chikungunya viruses, as well as the mosquitoes that transmit them. We are also involved in developing novel methods for detecting emerging viruses in resource-poor settings such as rural West Africa.

We take a multidisciplinary approach to science that combines classical virology, entomology, and molecular and computational biology. Central concepts that guide our work include the notion that arthropod-borne viruses, like other RNA viruses, form genetically complex populations within individual hosts, and that natural selection powerfully shapes which of these variants are most fit in a given environment. We are also active in local health initiatives that consist mainly of efforts to limit the impact of West Nile virus in Fort Collins and elsewhere on the great plains. The Ebel lab is also a part of the Rockies and High Plains Vector-borne Diseases Center, a regional training and evaluation center funded by the CDC.

Statement on Inclusion and Anti-Racism

research project

Quasispecies dynamics in arbovirus persistence emergence and fitness

view project
research project

Predicting genetic determinants of Zika virus emergence

view project
research project

Emergence of tick-borne encephalitis in North America

view project
research project

Role of cell tropism for Zika virus pathogenesis and transmission

view project
research project

Engineering therapies that evolve to autonomously control epidemics

view project


Intrinsic factors driving mosquito vector competence and viral evolution: a review.
Lewis J, Gallichotte EN, Randall J, Glass A, Foy BD, Ebel GD, Kading RC. Front Cell Infect Microbiol. 2023 Dec 21;13:1330600. doi: 10.3389/fcimb.2023.1330600. eCollection 2023. PMID: 38188633

On the origin and evolution of the mosquito male-determining factor Nix.
Biedler JK, Aryan A, Qi Y, Wang A, Martinson EO, Hartman DA, Yang F, Sharma A, Morton KS, Potters M, Chen C, Dobson SL, Ebel GD, Kading RC, Paulson S, Xue RD, Strand MR, Tu Z. Mol Biol Evol. 2023 Dec 21:msad276. doi: 10.1093/molbev/msad276. Online ahead of print. PMID: 38128148

Evaluation of Vector-Enabled Xenosurveillance in Rural Guatemala.
McMinn RJ, Chacon A, Rückert C, Scorza V, Young MC, Worthington D, Lamb MM, Medrano RE, Harris EK, Arias K, Lopez MR, Asturias EJ, Foy BD, Stenglein MD, Olson D, Ebel GD. Am J Trop Med Hyg. 2023 Oct 16;109(6):1303-1310. doi: 10.4269/ajtmh.22-0774. Print 2023 Dec 6. PMID: 37972312

Colorado tick fever virus: a review of historical literature and research emphasis for a modern era.
Harris EK, Foy BD, Ebel GD. J Med Entomol. 2023 Nov 14;60(6):1214-1220. doi: 10.1093/jme/tjad094. PMID: 37862094

Vertebrate-class-specific binding modes of the alphavirus receptor MXRA8.
Zimmerman O, Zimmerman MI, Raju S, Nelson CA, Errico JM, Madden EA, Holmes AC, Hassan AO, VanBlargan LA, Kim AS, Adams LJ, Basore K, Whitener BM, Palakurty S, Davis-Adams HG, Sun C, Gilliland T Jr, Earnest JT, Ma H, Ebel GD, Zmasek C, Scheuermann RH, Klimstra WB, Fremont DH, Diamond MS.Cell. 2023 Oct 26;186(22):4818-4833.e25. doi: 10.1016/j.cell.2023.09.007. Epub 2023 Oct 6. PMID: 37804831

more publications


Greg Ebel, Sc.D.

Lab Principal Investigator [PI]
Director, Center for Vector-Borne Infectious Diseases

news and updates view all