Foy Lab

As a member of the Center for Vector-Borne Infectious Diseases (CVID) at Colorado State University, the Foy laboratory focuses on the interactions of vectors with their hosts and with vector pathogens. The goal is to link research employing molecular, proteomic and genomic techniques to practical applications for controlling arthropod-borne diseases. A main research component in the Foy lab is to interrupt the intense transmission of malaria and arboviruses by targeting the vector through their bloodmeals using drugs that attack vector physiology and that inhibit pathogen development or using anti-vector immunity driven by vaccination. The Foy lab is also developing mosquitoes and other vectors as biosurveillance tools, studying unique aspects of arbovirus transmission and arbovirus survival in vectors, and studying poorly understood mosquito pathogens for their prospects to become vector-borne disease control tools.

The Foy lab is hiring for a Research Associate II position

The applicant will be involved primarily in research with mosquitoes and mosquito-borne infectious pathogens. The position also requires experience in rearing arthropod vectors (mosquitoes and other vectors) in our insectaries, and the ability to conduct molecular/cellular assays and perform experiments with arthropod vectors and the pathogens they transmit (arboviruses like West Nile virus, Plasmodium, etc.). It is preferred that the applicant have work experience collecting, handling and identification of mosquitoes in the field, experience in BSL-2 and/or BSL-3 laboratories, working with infectious pathogens, and/or animal handling.

Applicants must hold a minimum of a bachelor’s degree in a health sciences-related field and have 2 or more years of laboratory experience in microbiology (or related field), with practical experience with arboviruses and/or mosquitoes. The successful candidate will possess a strong work ethic and organizational and communication skills, knowledge of standard computer applications used in laboratory and field research, and the ability to work productively and collegially as a member of a large and diverse research team.

Please contact Brian Foy via email and apply to the MIP Research Associates I, II, or III Open Pool.

research project

Repeat Ivermectin Mass Drug Administrations for Malaria control II (RIMDAMAL II)

This is a cluster randomized clinical trial in Burkina Faso to test whether repeated ivermectin mass drug administrations, integrated into a monthly delivery platform with standard malaria control measures of seasonal malaria chemoprevention and insecticide-treated bed net distribution, will reduce childhood malaria incidence and limit resistance development in mosquitoes and parasites.

research project

TRANSMIT: Tracking Antimalarial Resistance in Mosquito Populations

This project is designed to compare malaria parasite drug resistance tracking techniques using human blood samples versus using captured blood fed mosquito samples.

research project

Comparison of mosquito age-grading measures in the RIMDAMAL II randomized, double-blind clinical trial

This project is comparing new and old mosquito age grading techniques within the context of our RIMDAMAL II clinical trial to best determine how different vector-control measures mosquito population age structure.

research project

Aedes-borne arbovirus transmission

We are studying humans and animal models to characterize the viral dynamics, host responses and disease outcomes resulting from Aedes-borne arbovirus transmission. We are especially interested in understanding these outcomes from Zika virus transmission by the sexual and mosquito-borne routes. Our human studies partners are researchers at FIOCRUZ, Aggeu Magalhaes Institute, Recife, PE, Brazil.

research project

Endectocides for West Nile virus control

This project designed to develop and test endectocide-treated bird feed for efficacy in controlling West Nile virus transmission. Our partners are colleagues at UC-Davis, CDC-DVBD, and TDA Research, Inc.

Publications

Effects of ivermectin treatment of backyard chickens on mosquito dynamics and West Nile virus transmission.

Holcomb KM, Nguyen C, Foy BD, Ahn M, Cramer K, Lonstrup ET, Mete A, Tell LA, Barker CM.
PLoS Negl Trop Dis. 2022 Mar 25;16(3):e0010260. doi: 10.1371/journal.pntd.0010260. eCollection 2022 Mar. PMID: 35333866

Three Immunocompetent Small Animal Models That Do Not Support Zika Virus Infection.

Miller MR, Fagre AC, Clarkson TC, Markle ED, Foy BD.
Pathogens. 2021 Jul 30;10(8):971. doi: 10.3390/pathogens10080971. PMID: 34451435

Characterization of subclinical ZIKV infection in immune-competent guinea pigs and mice.

Westrich JA, McNulty EE, Edmonds MJ, Nalls AV, Miller MR, Foy BD, Rovnak J, Perera R, Mathiason CK.
J Gen Virol. 2021 Aug;102(8):001641. doi: 10.1099/jgv.0.001641. PMID: 34410903

Design and analysis of a 2-year parallel follow-up of repeated ivermectin mass drug administrations for control of malaria: Small sample considerations for cluster-randomized trials with count data.

Jackson CL, Colborn K, Gao D, Rao S, Slater HC, Parikh S, Foy BD, Kittelson J.
Clin Trials. 2021 Oct;18(5):582-593. doi: 10.1177/17407745211028581. Epub 2021 Jul 3. PMID: 34218684

Nootkatone Is an Effective Repellent against Aedes aegypti and Aedes albopictus.

Clarkson TC, Janich AJ, Sanchez-Vargas I, Markle ED, Gray M, Foster JR, Black Iv WC, Foy BD, Olson KE.
Insects. 2021 Apr 27;12(5):386. doi: 10.3390/insects12050386. PMID: 33925333

more publications

People

Brian Foy, Ph.D.

Lab Principal Investigator [PI]
Professor

Teca Magalhaes, Ph.D.

Affiliate Faculty/Collaborator

Paula Lado, Ph.D.

Postdoctoral Fellow

Chilinh Nguyen, Ph.D.

Postdoctoral Fellow

Greg Pugh

Graduate Research Assistant

Michelle Savran

Graduate Research Assistant

Anna Sophia Leon

Student Researcher

Molly Ring

Student Researcher

Chilinh Nguyen and Brian Foy building field study boxes.

Soleil Foy and Jasmine Donkoh in the insectary.

Erin Markle presenting her undergraduate research.

Members of the Foy lab participated in a local March for Science.

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