Geiss Lab

Our group’s focus, as part of the Center for Vector-Borne Infectious Diseases (CVID), is to understand how RNA viruses replicate at the molecular and biochemical levels in order to develop novel strategies for the prevention and treatment of arboviral diseases. We are also interested in developing novel virus-based tools that can be used by the wider scientific community. We use a wide range of tools (classical virology, molecular biology, cell biology, biochemistry, engineering, computational biology, etc.) to understand how these important human pathogens replicate and use this information to help improve human and animal health.

research project

Mechanism of Flavivirus RNA Capping

Mosquito-borne flaviviruses are a continuing public health threat. There are currently few vaccines available against flaviviruses and no antiviral therapeutics available for clinical use. This project will provide insight for the development of new antivirals and vaccines to combat these pathogens.

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research project

Real Time Monitor for Airborne Viral Pathogens

The Geiss lab and ADev staff have developed carbon-based electrode arrays that are capable of detecting virus particles, a way to modify carbon electrodes with affinity agents that can selectively bind either virus particle simulants and/or virus particles, and a method for integrating working elect.

Publications

Deciphering the interaction surface between the West Nile virus NS3 and NS5 proteins.
Brand C, Geiss BJ, Bisaillon M. Access Microbiol. 2024 Jun 26;6(6):000675.v3. doi: 10.1099/acmi.0.000675.v3. eCollection 2024. PMID: 39045235

PAbFold: Linear Antibody Epitope Prediction using AlphaFold2.
DeRoo J, Terry JS, Zhao N, Stasevich TJ, Snow CD, Geiss BJ. bioRxiv [Preprint]. 2024 Apr 19:2024.04.19.590298. doi: 10.1101/2024.04.19.590298.PMID: 38659833

Multiplexed Capillary-Flow Driven Immunoassay for Respiratory Illnesses.
Link JS, O’Donnell-Sloan J, Curdts S, Geiss BJ, Dandy DS, Henry CS. Anal Chem. 2024 Mar 12;96(10):4111-4119. doi: 10.1021/acs.analchem.3c04977. Epub 2024 Feb 28.PMID: 38417100

The leader RNA of SARS-CoV-2 sequesters polypyrimidine tract binding protein (PTBP1) and influences pre-mRNA splicing in infected cells.
Altina NH, Maranon DG, Anderson JR, Donaldson MK, Elmegerhi S, St Clair LA, Perera R, Geiss BJ, Wilusz J. Virology. 2024 Apr;592:109986. doi: 10.1016/j.virol.2024.109986. Epub 2024 Jan 6.PMID: 38290414

Capillary flow-driven immunoassay platform for COVID-19 antigen diagnostics.
Link JS, Carrell CS, Jang I, Barstis EJO, Call ZD, Bellows RA, O’Donnell-Sloan JJ, Terry JS, Anderson LBR, Panraksa Y, Geiss BJ, Dandy DS, Henry CS. Anal Chim Acta. 2023 Oct 9;1277:341634. doi: 10.1016/j.aca.2023.341634. Epub 2023 Jul 27. PMID: 37604607

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People

Brian Geiss, Ph.D.

Principal Investigator [PI]
Professor

Handly Mayton, Ph.D.

Postdoctoral Fellow

Michael Mingroni, Ph.D.

Postdoctoral Fellow

Marina Fujii

Ph.D. Student, Microbiology

Lauren Malsick, M.A.

Ph.D. Student, Microbiology

Kimberly Robins

Ph.D. Student, Microbiology

Brooke Enney

Research Associate I

Amanda Bartels

Student Researcher

The 2023 Geiss Lab Crew

The 2021 Geiss Lab Crew

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