Our group’s focus, as part of the Center for Vector-Borne Infectious Diseases (CVID), is to understand how RNA viruses replicate at the molecular and biochemical levels in order to develop novel strategies for the prevention and treatment of arboviral diseases. We are also interested in developing novel virus-based tools that can be used by the wider scientific community. We use a wide range of tools (classical virology, molecular biology, cell biology, biochemistry, engineering, computational biology, etc.) to understand how these important human pathogens replicate and use this information to help improve human and animal health.
Dr. Brian Geiss is the director of the Online Master of Science in Microbiology – Immunology program. Designed to be completed in one or two years, this non-thesis program strengthens the scientific academic portfolio of those seeing terminal professional degrees and provides preparation for those seeking careers in biotechnology and research.
Mechanism of Flavivirus RNA Capping
Mosquito-borne flaviviruses are a continuing public health threat. There are currently few vaccines available against flaviviruses and no antiviral therapeutics available for clinical use. This project will provide insight for the development of new antivirals and vaccines to combat these pathogens.view project
Real Time Monitor for Airborne Viral Pathogens
The Geiss lab and ADev staff have developed carbon-based electrode arrays that are capable of detecting virus particles, a way to modify carbon electrodes with affinity agents that can selectively bind either virus particle simulants and/or virus particles, and a method for integrating working elect.
Development of a SARS-CoV-2 nucleocapsid specific monoclonal antibody.
Terry JS, Anderson LB, Scherman MS, McAlister CE, Perera R, Schountz T, Geiss BJ.
Virology. 2021 Jun;558:28-37. doi: 10.1016/j.virol.2021.01.003. Epub 2021 Feb 1. PMID: 33714753
SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for spillback to New World rodents.
Fagre A, Lewis J, Eckley M, Zhan S, Rocha SM, Sexton NR, Burke B, Geiss B, Peersen O, Bass T, Kading R, Rovnak J, Ebel GD, Tjalkens RB, Aboellail T, Schountz T.
PLoS Pathog. 2021 May 19;17(5):e1009585. doi: 10.1371/journal.ppat.1009585. eCollection 2021 May. PMID: 34010360
Conserved motifs in the flavivirus NS3 RNA helicase enzyme.
Du Pont KE, McCullagh M, Geiss BJ.
Wiley Interdiscip Rev RNA. 2022 Mar;13(2):e1688. doi: 10.1002/wrna.1688. Epub 2021 Sep 2. PMID: 34472205
Electrochemical Immunoassay for the Detection of SARS-CoV-2 Nucleocapsid Protein in Nasopharyngeal Samples.
Samper IC, McMahon CJ, Schenkel MS, Clark KM, Khamcharoen W, Anderson LBR, Terry JS, Gallichotte EN, Ebel GD, Geiss BJ, Dandy DS, Henry CS.
Anal Chem. 2022 Mar 22;94(11):4712-4719. doi: 10.1021/acs.analchem.1c04966. Epub 2022 Mar 9. PMID: 35263100
A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes.
Du Pont KE, Sexton NR, McCullagh M, Ebel GD, Geiss BJ.
J Virol. 2020 Sep 15;94(19):e01021-20. doi: 10.1128/JVI.01021-20. Print 2020 Sep 15. PMID: 32699093
Principal Investigator [PI]
Director, Online Microbiology - Immunology Master's Program
Research Associate II
Graduate Research Assistant
Ph.D. Student, Microbiology
Ph.D. Student, Microbiology
The 2021 Geiss Lab Crew
news and updates view all
Brian Geiss shares his thoughts on receiving the Best Teacher Award in 2020.
What is it that puts older people at increased risk from viruses like SARS-CoV-2?
The CSU developed COVID-19 biosensor test could produce results from blood, saliva or nasal swab sample in 30 minutes at home for a low cost.
Lab: Microbiology Room B430
Office: Microbiology Room B409