Geiss Lab

Our group’s focus, as part of the Center for Vector-Borne Infectious Diseases (CVID), is to understand how RNA viruses replicate at the molecular and biochemical levels in order to develop novel strategies for the prevention and treatment of arboviral diseases. We are also interested in developing novel virus-based tools that can be used by the wider scientific community. We use a wide range of tools (classical virology, molecular biology, cell biology, biochemistry, engineering, computational biology, etc.) to understand how these important human pathogens replicate and use this information to help improve human and animal health.

research project

Real Time Monitor for Airborne Viral Pathogens

The Geiss lab and ADev staff have developed carbon-based electrode arrays that are capable of detecting virus particles, a way to modify carbon electrodes with affinity agents that can selectively bind either virus particle simulants and/or virus particles, and a method for integrating working elect.

Publications

Detection of Aerosolized Protein Using a Condensation Growth Tube Coupled with an Electrochemical Immunoassay on Screen-Printed Carbon Electrodes.
Park J, Baldo TA, Unruh B, Stump B, Heskett D, Keady P, Annis B, Geiss BJ, Dandy DS, Henry CS. Anal Chem. 2026 Apr 20. doi: 10.1021/acs.analchem.6c00185. Online ahead of print. PMID: 42011020

Motif V is an allosteric couple between the SARS-CoV-2 nsp13 nucleotide triphosphatase and helicase active sites
Mingroni MA, Enney BM, Malsick LE, Geiss BJ. . J Biol Chem. 2026 Jan 23;302(3):111198. doi: 10.1016/j.jbc.2026.111198. Epub ahead of print. PMID: 41581884.

Development of ENTV reverse genetics system and phenotypic evaluation of rescued virus reveals host-specific replication patterns in mosquitoes.
Fujii M, Gallichotte EN, Sanchez-Vargas I, Enney BM, Malsick LE, Ebel GD, Geiss BJ. bioRxiv [Preprint]. 2025 Jul 29:2025.07.29.667424. doi: 10.1101/2025.07.29.667424. PMID: 40766458 Free PMC article. Preprint.

Magnetic bead-based electrochemical surrogate virus neutralization test for quantification of antibody neutralizing efficiency.
Bellows RA, Rahn KL, Hummel WC, Mayton EH, Berry HW, Ryan EP, Geiss BJ, Dandy DS, Henry CS.
Biosens Bioelectron. 2025 May 30;287:117640. doi: 10.1016/j.bios.2025.117640. Online ahead of print. PMID: 40554384

AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications.
Galindo G, Maejima D, DeRoo J, Burlingham SR, Fixen G, Morisaki T, Febvre HP, Hasbrook R, Zhao N, Ghosh S, Mayton EH, Snow CD, Geiss BJ, Ohkawa Y, Sato Y, Kimura H, Stasevich TJ. bioRxiv [Preprint]. 2025 Feb 9:2025.02.06.636921. doi: 10.1101/2025.02.06.636921.PMID: 39975170

more publications

People

Brian Geiss
Brian Geiss, Ph.D.

Principal Investigator [PI]
Professor

Handly Mayton, Ph.D.

Postdoctoral Fellow

John Anderson

Research Associate II

Marina Fujii

Ph.D. Student, Microbiology

Brooke Enney

Research Associate I/Lab Manager

David Chen

Undergraduate Researcher

Gold background with green graduation cap.
Geiss Lab Alumni

The 2023 Geiss Lab Crew

The 2021 Geiss Lab Crew

news and updates view all

January 13, 2026 AI tools speed development of antibody probes to see activity inside living cells 

A new paper on AI based research to aid imaging of living cells includes authors from the College of Natural Sciences, Walter Scott, Jr. College of Engineering and the College of Veterinary Medicine and Biomedical Sciences.
October 23, 2025 Students shine at Rocky Mountain Virology Conference

Lauren Malsick, a graduate student in the Geiss lab, earned second place in the student talk competition.
April 22, 2025 MIP student receives 2025 One Health Student Award

Lauren Malsick, a graduate researcher in the Geiss lab, received the award to investigate why the bat immune system can prevent illness from these viruses and the potential implications to better protect people.