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Geiss Lab

Our group’s focus, as part of the Center for Vector-Borne Infectious Diseases (CVID), is to understand how RNA viruses replicate at the molecular and biochemical levels in order to develop novel strategies for the prevention and treatment of arboviral diseases. We are also interested in developing novel virus-based tools that can be used by the wider scientific community. We use a wide range of tools (classical virology, molecular biology, cell biology, biochemistry, engineering, computational biology, etc.) to understand how these important human pathogens replicate and use this information to help improve human and animal health.

research project

Mechanism of Flavivirus RNA Capping

Mosquito-borne flaviviruses are a continuing public health threat. There are currently few vaccines available against flaviviruses and no antiviral therapeutics available for clinical use. This project will provide insight for the development of new antivirals and vaccines to combat these pathogens.

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research project

Real Time Monitor for Airborne Viral Pathogens

The Geiss lab and ADev staff have developed carbon-based electrode arrays that are capable of detecting virus particles, a way to modify carbon electrodes with affinity agents that can selectively bind either virus particle simulants and/or virus particles, and a method for integrating working elect.

Publications

Capillary driven microfluidic sequential flow device for point-of-need ELISA: COVID-19 serology testing.
Carrell C, Jang I, Link J, Terry JS, Call Z, Panraksa Y, Chailapakul O, Dandy DS, Geiss BJ, Henry CS.Anal Methods. 2023 Apr 26. doi: 10.1039/d3ay00225j. Online ahead of print. PMID: 37099406

Electrochemical Capillary Driven Immunoassay for Detection of SARS-CoV-2.
Clark KM, Schenkel MS, Pittman TW, Samper IC, Anderson LBR, Khamcharoen W, Elmegerhi S, Perera R, Siangproh W, Kennan AJ, Geiss BJ, Dandy DS, Henry CS.ACS Meas Sci Au. 2022 Dec 21;2(6):584-594. doi: 10.1021/acsmeasuresciau.2c00037. Epub 2022 Aug 30. PMID: 36570470

Progress toward a Simplified UTI Diagnostic: Pump-Free Magnetophoresis for E. coli Detection.
Call ZD, Jang I, Geiss BJ, Dandy DS, Henry CS.Anal Chem. 2022 May 31;94(21):7545-7550. doi: 10.1021/acs.analchem.2c00316. Epub 2022 May 19. PMID: 35588209

Electrochemical Immunoassay for the Detection of SARS-CoV-2 Nucleocapsid Protein in Nasopharyngeal Samples.
Samper IC, McMahon CJ, Schenkel MS, Clark KM, Khamcharoen W, Anderson LBR, Terry JS, Gallichotte EN, Ebel GD, Geiss BJ, Dandy DS, Henry CS.
Anal Chem. 2022 Mar 22;94(11):4712-4719. doi: 10.1021/acs.analchem.1c04966. Epub 2022 Mar 9. PMID: 35263100

A Hyperactive Kunjin Virus NS3 Helicase Mutant Demonstrates Increased Dissemination and Mortality in Mosquitoes.
Du Pont KE, Sexton NR, McCullagh M, Ebel GD, Geiss BJ.
J Virol. 2020 Sep 15;94(19):e01021-20. doi: 10.1128/JVI.01021-20. Print 2020 Sep 15. PMID: 32699093

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