Geiss Lab

Our group’s focus, as part of the Center for Vector-Borne Infectious Diseases (CVID), is to understand how RNA viruses replicate at the molecular and biochemical levels in order to develop novel strategies for the prevention and treatment of arboviral diseases. We are also interested in developing novel virus-based tools that can be used by the wider scientific community. We use a wide range of tools (classical virology, molecular biology, cell biology, biochemistry, engineering, computational biology, etc.) to understand how these important human pathogens replicate and use this information to help improve human and animal health.

research project

Mechanism of Flavivirus RNA Capping

Mosquito-borne flaviviruses are a continuing public health threat. There are currently few vaccines available against flaviviruses and no antiviral therapeutics available for clinical use. This project will provide insight for the development of new antivirals and vaccines to combat these pathogens.

view project
research project

Real Time Monitor for Airborne Viral Pathogens

The Geiss lab and ADev staff have developed carbon-based electrode arrays that are capable of detecting virus particles, a way to modify carbon electrodes with affinity agents that can selectively bind either virus particle simulants and/or virus particles, and a method for integrating working elect.


Capillary flow-driven immunoassay platform for COVID-19 antigen diagnostics.
Link JS, Carrell CS, Jang I, Barstis EJO, Call ZD, Bellows RA, O’Donnell-Sloan JJ, Terry JS, Anderson LBR, Panraksa Y, Geiss BJ, Dandy DS, Henry CS. Anal Chim Acta. 2023 Oct 9;1277:341634. doi: 10.1016/j.aca.2023.341634. Epub 2023 Jul 27. PMID: 37604607

Kunjin Virus, Zika Virus, and Yellow Fever Virus Infections Have Distinct Effects on the Coding Transcriptome and Proteome of Brain-Derived U87 Cells.
Brand C, Deschamps-Francoeur G, Bullard-Feibelman KM, Scott MS, Geiss BJ, Bisaillon M.Viruses. 2023 Jun 23;15(7):1419. doi: 10.3390/v15071419. PMID: 37515107

Nucleocapsid protein binding DNA aptamers for detection of SARS-COV-2.
Neff CP, Cikara M, Geiss BJ, Thomas Caltagirone G, Liao A, Atif SM, Macdonald B, Schaden R. Curr Res Biotechnol. 2023;5:100132. doi: 10.1016/j.crbiot.2023.100132. Epub 2023 May 27. PMID: 37275459

Capillary driven microfluidic sequential flow device for point-of-need ELISA: COVID-19 serology testing.
Carrell C, Jang I, Link J, Terry JS, Call Z, Panraksa Y, Chailapakul O, Dandy DS, Geiss BJ, Henry CS.Anal Methods. 2023 Apr 26. doi: 10.1039/d3ay00225j. Online ahead of print. PMID: 37099406

Electrochemical Capillary Driven Immunoassay for Detection of SARS-CoV-2.
Clark KM, Schenkel MS, Pittman TW, Samper IC, Anderson LBR, Khamcharoen W, Elmegerhi S, Perera R, Siangproh W, Kennan AJ, Geiss BJ, Dandy DS, Henry CS.ACS Meas Sci Au. 2022 Dec 21;2(6):584-594. doi: 10.1021/acsmeasuresciau.2c00037. Epub 2022 Aug 30. PMID: 36570470

more publications


Brian Geiss, Ph.D.

Principal Investigator [PI]
Associate Department Head for Graduate Education

Handly Mayton, Ph.D.

Postdoctoral Fellow

Michael Mingroni, Ph.D.

Postdoctoral Fellow

Marina Fujii

Ph.D. Student, Microbiology

Lauren Malsick, M.A.

Ph.D. Student, Microbiology

Kimberly Robins

Ph.D. Student, Microbiology

James Terry, M.S.

Ph.D. Student, Microbiology

Brooke Enney

Research Associate I

Amanda Bartels

Student Researcher

The 2023 Geiss Lab Crew

The 2021 Geiss Lab Crew

news and updates view all