Geiss Lab

Our group’s focus, as part of the Center for Vector-Borne Infectious Diseases (CVID), is to understand how RNA viruses replicate at the molecular and biochemical levels in order to develop novel strategies for the prevention and treatment of arboviral diseases. We are also interested in developing novel virus-based tools that can be used by the wider scientific community. We use a wide range of tools (classical virology, molecular biology, cell biology, biochemistry, engineering, computational biology, etc.) to understand how these important human pathogens replicate and use this information to help improve human and animal health.

research project

Real Time Monitor for Airborne Viral Pathogens

The Geiss lab and ADev staff have developed carbon-based electrode arrays that are capable of detecting virus particles, a way to modify carbon electrodes with affinity agents that can selectively bind either virus particle simulants and/or virus particles, and a method for integrating working elect.

Publications

AI-assisted protein design to rapidly convert antibody sequences to intrabodies targeting diverse peptides and histone modifications.
Galindo G, Maejima D, DeRoo J, Burlingham SR, Fixen G, Morisaki T, Febvre HP, Hasbrook R, Zhao N, Ghosh S, Mayton EH, Snow CD, Geiss BJ, Ohkawa Y, Sato Y, Kimura H, Stasevich TJ. bioRxiv [Preprint]. 2025 Feb 9:2025.02.06.636921. doi: 10.1101/2025.02.06.636921.PMID: 39975170

Deciphering the interaction surface between the West Nile virus NS3 and NS5 proteins.
Brand C, Geiss BJ, Bisaillon M. Access Microbiol. 2024 Jun 26;6(6):000675.v3. doi: 10.1099/acmi.0.000675.v3. eCollection 2024. PMID: 39045235

PAbFold: Linear Antibody Epitope Prediction using AlphaFold2.
DeRoo J, Terry JS, Zhao N, Stasevich TJ, Snow CD, Geiss BJ. bioRxiv [Preprint]. 2024 Apr 19:2024.04.19.590298. doi: 10.1101/2024.04.19.590298.PMID: 38659833

Multiplexed Capillary-Flow Driven Immunoassay for Respiratory Illnesses.
Link JS, O’Donnell-Sloan J, Curdts S, Geiss BJ, Dandy DS, Henry CS. Anal Chem. 2024 Mar 12;96(10):4111-4119. doi: 10.1021/acs.analchem.3c04977. Epub 2024 Feb 28.PMID: 38417100

The leader RNA of SARS-CoV-2 sequesters polypyrimidine tract binding protein (PTBP1) and influences pre-mRNA splicing in infected cells.
Altina NH, Maranon DG, Anderson JR, Donaldson MK, Elmegerhi S, St Clair LA, Perera R, Geiss BJ, Wilusz J. Virology. 2024 Apr;592:109986. doi: 10.1016/j.virol.2024.109986. Epub 2024 Jan 6.PMID: 38290414

more publications

People

Brian Geiss
Brian Geiss, Ph.D.

Principal Investigator [PI]
Professor

Handly Mayton, Ph.D.

Postdoctoral Fellow

Michael Mingroni, Ph.D.

Research Scientist I

Marina Fujii

Ph.D. Student, Microbiology

Lauren Malsick
Lauren Malsick, M.A.

Ph.D. Student, Microbiology

Kimberly Robins

Ph.D. Student, Microbiology

Brooke Enney

Research Associate I/Lab Manager

No photo Icon.
Amanda Bartels

Student Researcher

Gold background with green graduation cap.
Geiss Lab Alumni

The 2023 Geiss Lab Crew

The 2021 Geiss Lab Crew

news and updates view all

April 22, 2025 MIP student receives 2025 One Health Student Award

Lauren Malsick, a graduate researcher in the Geiss lab, received the award to investigate why the bat immune system can prevent illness from these viruses and the potential implications to better protect people.
April 14, 2025 AI-powered research

Chris Snow, along with Brian Geiss and Tim Stasevich, is using AI tools to aid in biomolecular engineering research.

August 29, 2024 CSU engineering professor creates new protein designs with revolutionary AI toolbox

Microbiology PhD student Kimberly Robins, co-advised by Brian Geiss and Chris Snow, is taking advantage of a suite of exciting machine-learning tools working together to help create new and profound protein designs.