The Gonzalez-Juarrero laboratory, part of the Mycobacteria Research Laboratories, focuses on the immune pathogenesis and development of aerosol therapies for mycobacterial diseases with primary emphasis on tuberculosis (TB) and non-tuberculous (NTM) diseases. Specifically, we want to understand how to enhance the antimicrobial activity in the infected host and characterize how these therapies affect the immunopathology of the disease, with an end goal of improved treatment therapies against multidrug-resistant infections.
We have developed several experimental animal models that allows for testing of aerosolized anti-TB and anti-NTM drugs. We test for efficacy, toxicity and pharmacokinetics of immunomodulators/antibiotics and study the temporal and spatial relationships of immune biomarkers during the stages of disease and therapy. Studies are done by a team of research scientists in close collaboration with other scientists in the mycobacteria research laboratories and serve to build a new generation of scientists by training graduate and undergraduate students.
Intrapulmonary Treatment with Mycobacteriophage LysB Rapidly Reduces Mycobacterium abscessus Burden.
Antimicrob Agents Chemother. 2023 May 8:e0016223. doi: 10.1128/aac.00162-23. Online ahead of print.PMID: 37154689
Characterization of spectinamide 1599 efficacy against different mycobacterial phenotypes.
Tuberculosis (Edinb). 2023 Apr 20;140:102342. doi: 10.1016/j.tube.2023.102342. Online ahead of print.PMID: 37120915
Spray dried tigecycline dry powder aerosols for the treatment of Nontuberculous mycobacterial pulmonary infections.
Tuberculosis (Edinb). 2023 Mar;139:102306. doi: 10.1016/j.tube.2023.102306. Epub 2023 Jan 20.PMID: 36716525
Mucosal exposure to non-tuberculous mycobacteria elicits B cell-mediated immunity against pulmonary tuberculosis.
Cell Rep. 2022 Dec 13;41(11):111783. doi: 10.1016/j.celrep.2022.111783.PMID: 36516760
Microbiological profile, preclinical pharmacokinetics and efficacy of CRS0393, a novel antimycobacterial agent targeting MmpL3.
Ochsner UA, De Groote MA, Jarvis TC, Liu H, Youmans T, Hoang T, Ribble W, Day J, Li W, Pearce C, Walz A, Panthi CM, Rimal B, Stevens CM, Zgurskaya HI, Jackson M, Ordway D, Gonzalez-Juarrero M, Sun X, Lamichhane G, Mason C.
Tuberculosis (Edinb). 2022 Nov 29;138:102288. doi: 10.1016/j.tube.2022.102288. Online ahead of print. PMID: 36470124
Principal Investigator [PI]
Research Associate II
Research Associate I
Research Associate I
Image of foamy macrophages from the granuloma of a mouse lung infected with Mtb. The lipids are fluorescent red, the bacilli green, and the cell nuclei are stained blue.
Immunohistochemistry showing IL-10 expression (brown) in Mtb infected lung tissue.
Multiplex immunohistochemistry for different cellular markers in and around a necrotic granuloma.
Multiplex immunohistochemistry in the lung tissue section from a balb/c mouse with Mtb. Each unique color is indicative of a unique cell type.
Lab: Microbiology room B230
Office: Microbiology room C223
Office: (970) 491-7306, Lab: (970) email@example.com