Gonzalez-Juarrero Lab

The Gonzalez-Juarrero laboratory, part of the Mycobacteria Research Laboratories, focuses on the immune pathogenesis and development of aerosol therapies for mycobacterial diseases with primary emphasis on tuberculosis (TB) and non-tuberculous (NTM) diseases. Specifically, we want to understand how to enhance the antimicrobial activity in the infected host and characterize how these therapies affect the immunopathology of the disease, with an end goal of improved treatment therapies against multidrug-resistant infections.

We have developed several experimental animal models that allows for testing of aerosolized anti-TB and anti-NTM drugs. We test for efficacy, toxicity and pharmacokinetics of immunomodulators/antibiotics and study the temporal and spatial relationships of immune biomarkers during the stages of disease and therapy. Studies are done by a team of research scientists in close collaboration with other scientists in the mycobacteria research laboratories and serve to build a new generation of scientists by training graduate and undergraduate students.

Publications

Mycobacterium leprae Infection in a Wild Nine-Banded Armadillo, Nuevo León, Mexico.

Vera-Cabrera L, Ramos-Cavazos CJ, Youssef NA, Pearce CM, Molina-Torres CA, Avalos-Ramirez R, Gagneux S, Ocampo-Candiani J, Gonzalez-Juarrero M, Mayorga-Rodriguez JA, Mayorga-Garibaldi L, Spencer JS, Jackson M, Avanzi C.
Emerg Infect Dis. 2022 Mar;28(3):747-749. doi: 10.3201/eid2803.211295. PMID: 35202538

Therapeutic efficacy of antimalarial drugs targeting DosRS signaling in Mycobacterium abscessus.

Belardinelli JM, Verma D, Li W, Avanzi C, Wiersma CJ, Williams JT, Johnson BK, Zimmerman M, Whittel N, Angala B, Wang H, Jones V, Dartois V, de Moura VCN, Gonzalez-Juarrero M, Pearce C, Schenkel AR, Malcolm KC, Nick JA, Charman SA, Wells TNC, Podell BK, Vennerstrom JL, Ordway DJ, Abramovitch RB, Jackson M.
Sci Transl Med. 2022 Feb 23;14(633):eabj3860. doi: 10.1126/scitranslmed.abj3860. Epub 2022 Feb 23. PMID: 35196022

Unique Features of Mycobacterium abscessus Biofilms Formed in Synthetic Cystic Fibrosis Medium.

Belardinelli JM, Li W, Avanzi C, Angala SK, Lian E, Wiersma CJ, Palčeková Z, Martin KH, Angala B, de Moura VCN, Kerns C, Jones V, Gonzalez-Juarrero M, Davidson RM, Nick JA, Borlee BR, Jackson M.
Front Microbiol. 2021 Oct 29;12:743126. doi: 10.3389/fmicb.2021.743126. eCollection 2021. PMID: 34777289

Unique Features of Mycobacterium abscessus Biofilms Formed in Synthetic Cystic Fibrosis Medium.

Belardinelli JM, Li W, Avanzi C, Angala SK, Lian E, Wiersma CJ, Palčeková Z, Martin KH, Angala B, de Moura VCN, Kerns C, Jones V, Gonzalez-Juarrero M, Davidson RM, Nick JA, Borlee BR, Jackson M.
Front Microbiol. 2021 Oct 29;12:743126. doi: 10.3389/fmicb.2021.743126. eCollection 2021. PMID: 34777289

Lipid nanoparticle formulation of niclosamide (nano NCM) effectively inhibits SARS-CoV-2 replication in vitro.

Wang G, Gaikwad H, McCarthy MK, Gonzalez-Juarrero M, Li Y, Armstrong M, Reisdorph N, Morrison TE, Simberg D.
Precis Nanomed. 2021 Apr 17;4(1):724-737. doi: 10.33218/001c.18813. Epub 2021 Jan 17. PMID: 34676370

more publications

People

Mercedes Gonzalez-Juarrero, Ph.D.

Lab Principal Investigator [PI]
Professor

Ilham Alshiraihi, Ph.D.

Postdoctoral Fellow

Amanda Walz, M.S.

Research Associate III

Camron Pearce, M.S.

Research Associate II
PhD Candidate

John Patterson

Research Associate I

Ha Lam

Research Associate

Zohaib Ali headshot.
Zohaib Ali

PhD Candidate
Fulbright Scholar

Tucker Booth

Student Researcher

Sydney Fugate

Student Researcher

Abigail Godelfer

Student Researcher

Icon of a person on a green background.
Brandon Goral

Student Researcher

Icon of a person on a green background.
Diane Jimenez

Student Researcher

Icon of a person on a green background.
Jenna Randall

Student Researcher

Image of foamy macrophages from the granuloma of a mouse lung infected with Mtb. The lipids are fluorescent red, the bacilli green, and the cell nuclei are stained blue.

Immunohistochemistry showing IL-10 expression (brown) in Mtb infected lung tissue.

Multiplex immunohistochemistry for different cellular markers in and around a necrotic granuloma.

Multiplex immunohistochemistry in the lung tissue section from a balb/c mouse with Mtb. Each unique color is indicative of a unique cell type.