The Jeffrey Wilusz lab is interested in the mechanisms and regulation of mRNA metabolism in eukaryotic cells and how these processes influence pathogenesis of human diseases, including cancer, viral infection and myotonic dystrophy. We are also examining how mRNA decay contributes to the achievement and maintenance of pluripotency in stem cells.
research project
Flavivirus non-coding RNAs and the Host mRNA Decay Machinery
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research project
Indications Against Highly Pathogenic Agents for Transportable Pathogen Reduction and Blood Safety System for Whole Blood
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research project
COVID-19: Mechanisms and functional implications of SARS-CoV-2 mRNA capping and modification
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research project
Mechanism of Flavivirus RNA Capping
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Publications
UV damage induces production of mitochondrial DNA fragments with specific length profiles.
Waneka G, Stewart J, Anderson JR, Li W, Wilusz J, Argueso JL, Sloan DB. bioRxiv. 2023 Nov 11:2023.11.07.566130. doi: 10.1101/2023.11.07.566130. Preprint.PMID: 37986892
Dynamic “Cap”-abilities of P-bodies and the XRN1-EDC4 axis.
Malsick LE, Wilusz J. EMBO J. 2023 Nov 2;42(21):e115310. doi: 10.15252/embj.2023115310. Epub 2023 Sep 26. PMID: 37750488
A plant-infecting subviral RNA associated with poleroviruses produces a subgenomic RNA which resists exonuclease XRN1 in vitro.
Campbell AJ, Anderson JR, Wilusz J. Virology. 2022 Jan;566:1-8. doi: 10.1016/j.virol.2021.11.002. Epub 2021 Nov 17.PMID: 34808564
Aedes aegypti miRNA-33 modulates permethrin induced toxicity by regulating VGSC transcripts.
Kubik TD, Snell TK, Saavedra-Rodriguez K, Wilusz J, Anderson JR, Lozano-Fuentes S, Black WC 4th, Campbell CL. Sci Rep. 2021 Mar 31;11(1):7301. doi: 10.1038/s41598-021-86665-6.
Zika Virus Replication in Myeloid Cells during Acute Infection Is Vital to Viral Dissemination and Pathogenesis in a Mouse Model.
McDonald EM, Anderson J, Wilusz J, Ebel GD, Brault AC. J Virol. 2020 Oct 14;94(21):e00838-20. doi: 10.1128/JVI.00838-20. Print 2020 Oct 14. PMID: 32847848
more publications
People
Jeff Wilusz, Ph.D.
Lab Principal Investigator [PI]
Professor
Director, Online Microbiology-Immunology Masters Program
contact information
Office: Microbiology Room C330
Lab: Microbiology Room B325
(970) 491-4881
[email protected]
