Jeff Wilusz Lab

​​​​​​​The Jeffrey Wilusz lab is interested in the mechanisms and regulation of mRNA metabolism in eukaryotic cells and how these processes influence pathogenesis of human diseases, including cancer, viral infection and myotonic dystrophy. We are also examining how mRNA decay contributes to the achievement and maintenance of pluripotency in stem cells.​ 

research project

Flavivirus non-coding RNAs and the Host mRNA Decay Machinery

(Insert brief description of 400 characters including spaces and/or link about project here.)

research project

Indications Against Highly Pathogenic Agents for Transportable Pathogen Reduction and Blood Safety System for Whole Blood

(Insert brief description of 400 characters including spaces and/or link about project here.)

research project

COVID-19: Mechanisms and functional implications of SARS-CoV-2 mRNA capping and modification

(Insert brief description of 400 characters including spaces and/or link about project here.)

research project

Mechanism of Flavivirus RNA Capping

(Insert brief description of 400 characters including spaces and/or link about project here.)

Publications

A plant-infecting subviral RNA associated with poleroviruses produces a subgenomic RNA which resists exonuclease XRN1 in vitro.
Campbell AJ, Anderson JR, Wilusz J.
Virology. 2022 Jan;566:1-8. doi: 10.1016/j.virol.2021.11.002. Epub 2021 Nov 17.PMID: 34808564

Aedes aegypti miRNA-33 modulates permethrin induced toxicity by regulating VGSC transcripts.
Kubik TD, Snell TK, Saavedra-Rodriguez K, Wilusz J, Anderson JR, Lozano-Fuentes S, Black WC 4th, Campbell CL. Sci Rep. 2021 Mar 31;11(1):7301. doi: 10.1038/s41598-021-86665-6.

Zika Virus Replication in Myeloid Cells during Acute Infection Is Vital to Viral Dissemination and Pathogenesis in a Mouse Model.
McDonald EM, Anderson J, Wilusz J, Ebel GD, Brault AC.
J Virol. 2020 Oct 14;94(21):e00838-20. doi: 10.1128/JVI.00838-20. Print 2020 Oct 14. PMID: 32847848

The interface between coronaviruses and host cell RNA biology: Novel potential insights for future therapeutic intervention.
Maranon DG, Anderson JR, Maranon AG, Wilusz J.
Wiley Interdiscip Rev RNA. 2020 Sep;11(5):e1614. doi: 10.1002/wrna.1614. Epub 2020 Jul 7.

YTHDF2 destabilizes m6A-modified neural-specific RNAs to restrain differentiation in induced pluripotent stem cells.
Heck AM, Russo J, Wilusz J, Nishimura EO, Wilusz CJ.
RNA. 2020 Jun;26(6):739-755. doi: 10.1261/rna.073502.119. Epub 2020 Mar 13.

more publications

People

Jeff WIlusz headshot.
Jeff Wilusz, Ph.D.

Lab Principal Investigator [PI]
Professor
Director, Online Microbiology-Immunology Masters Program

David Maranon
David Maranon, Ph.D.

Research Scientist I

John Anderson
John Anderson, M.S.

Research Associate II

Noelia Altina
Noelia Altina, M.S.

Graduate Research Assistant

Meghan Donaldson
Meghan Donaldson

Student Researcher

Icon of a person on a green background.
Sawarot Srisathaporn

Coordinator

news and updates view all

May 4, 2020 College faculty, staff honored virtually for Celebrate! CSU 2020

Jeff Wilusz was awarded the 2020 Oliver P. Pennock Distinguished Service Award, which recognizes meritorious and outstanding achievement in the last five years.