Jeff Wilusz Lab

​​​​​​​The Jeffrey Wilusz lab is interested in the mechanisms and regulation of mRNA metabolism in eukaryotic cells and how these processes influence pathogenesis of human diseases, including cancer, viral infection and myotonic dystrophy. We are also examining how mRNA decay contributes to the achievement and maintenance of pluripotency in stem cells.​ 

research project

Flavivirus non-coding RNAs and the Host mRNA Decay Machinery

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research project

Indications Against Highly Pathogenic Agents for Transportable Pathogen Reduction and Blood Safety System for Whole Blood

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research project

COVID-19: Mechanisms and functional implications of SARS-CoV-2 mRNA capping and modification

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research project

Mechanism of Flavivirus RNA Capping

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Publications

Aedes aegypti miRNA-33 modulates permethrin induced toxicity by regulating VGSC transcripts.

Kubik TD, Snell TK, Saavedra-Rodriguez K, Wilusz J, Anderson JR, Lozano-Fuentes S, Black WC 4th, Campbell CL.
Sci Rep. 2021 Mar 31;11(1):7301. doi: 10.1038/s41598-021-86665-6.

Zika Virus Replication in Myeloid Cells during Acute Infection Is Vital to Viral Dissemination and Pathogenesis in a Mouse Model.

McDonald EM, Anderson J, Wilusz J, Ebel GD, Brault AC.
J Virol. 2020 Oct 14;94(21):e00838-20. doi: 10.1128/JVI.00838-20. Print 2020 Oct 14.PMID: 32847848

The interface between coronaviruses and host cell RNA biology: Novel potential insights for future therapeutic intervention.

Maranon DG, Anderson JR, Maranon AG, Wilusz J.
Wiley Interdiscip Rev RNA. 2020 Sep;11(5):e1614. doi: 10.1002/wrna.1614. Epub 2020 Jul 7.

YTHDF2 destabilizes m6A-modified neural-specific RNAs to restrain differentiation in induced pluripotent stem cells.

Heck AM, Russo J, Wilusz J, Nishimura EO, Wilusz CJ.
RNA. 2020 Jun;26(6):739-755. doi: 10.1261/rna.073502.119. Epub 2020 Mar 13.

Mind the Gapmer: Implications of Co-transcriptional Cleavage by Antisense Oligonucleotides.

Maranon DG, Wilusz J.
Mol Cell. 2020 Mar 5;77(5):932-933. doi: 10.1016/j.molcel.2020.02.010.

more publications

People

Jeff Wilusz, Ph.D.

Lab Principal Investigator [PI]
Professor

David Maranon, Ph.D.

Research Scientist I

John Anderson, M.S.

Research Associate II

Noelia Altina, M.S.

Graduate Research Assistant

Meghan Donaldson

Student Researcher

Bryn Erickson

Coordinator

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