The MacNeill Lab studies poxvirus pathogenesis and genetically engineers poxviruses to use as vaccines and oncolytic viruses. The lab is particularly interested in understanding molecular interactions between poxviruses and immune responses. In collaboration with the Flint Animal Cancer Center, recombinant poxviruses created in the lab are used in clinical trials to treat canine cancer patients.
The MacNeill Lab develops recombinant poxviruses for use as oncolytic agents. Clinical trials using oncolytic virotherapy in dogs and cats advance treatment options for dogs with cancer and may better predict human response to virotherapy than murine cancer models do.
Pathogens. 2022; 11(8):892. https://doi.org/10.3390/pathogens11080892
Khorsand M, Martabano BB, MacNeill A, Ehrhart N, Dubielzig RR, Teixeira L, Henriksen ML.
J Am Vet Med Assoc. 2022 Mar 12;259(S2):1-5. doi: 10.2460/javma.20.03.0155. PMID: 35349472
Ashton LV, Graham B, Afzali MF, Gustafson D, MacNeill AL.
Oncolytic Virother. 2020 May 26;9:17-29. doi: 10.2147/OV.S252727. eCollection 2020. PMID: 32548076
Ashton LV, Quackenbush SL, Castle J, Wilson G, McCoy J, Jordan M, MacNeill AL.
Viruses. 2020 May 8;12(5):517. doi: 10.3390/v12050517. PMID: 32397134
The potential of the combined use of targeted type I interferon pathway inhibitors and oncolytic viruses to treat sarcomas.
Vet Comp Oncol. 2020 Mar;18(1):36-42. doi: 10.1111/vco.12547. Epub 2019 Nov 5. PMID: 31618515
news and updates
Dr. MacNeill sat down with 9News reporter Jennifer Meckles to explain what she knows about monkeypox from studying past outbreaks, and its effect on animal species.
Amy MacNeill, of Colorado State University, studies pox viruses from a veterinary perspective, given that rodents so often spread the disease to people.
Amy MacNeill weighed in on how worried we should be about monkeypox, the threat of zoonotic spillover, and what differentiates this outbreak from the COVID-19 pandemic.
Office: Diagnostic Medicine Center 110
Lab: Diagnostic Medicine Center room ###