VandeWoude Lab

The VandeWoude Laboratory studies a variety of agents that infect domestic and nondomestic cats, most predominantly Feline Immunodeficiency Virus.

The mission of the VandeWoude Lab is to:

  • Train undergraduate, graduate, pre- and post-DVM students, and post-doctoral fellows in modern techniques in molecular virology, with emphasis on experimental design, data interpretation, and accurate and fluent reporting of results.
  • Strive to continuously develop new methodologies to apply to the research process.
  • Facilitate productive and collaborative interactions between SVRG lab members and collaborators both internal and external to CSU.
  • Extrapolate findings to whole animal and population health, in vivo relevance, and community/ecological impacts.
  • Challenge existing dogma with an open mind and thoughtful approach.
  • Generate enthusiasm and appreciation for the impact of well-considered scientific approaches on human and animal health and well-being.
  • Provide a supportive, lively, challenging, cooperative and fun environment for scientific investigations in complementary disciplines.

VandeWoude Lab Research Aims

research project

Feline Ecology: Landscapes, Infectious Disease, And Epidemics

There are many questions about the spread of disease in felines. The FELIDAE (Feline Ecology: Landscapes, Infectious Disease, And Epidemics) research project seeks to answer questions about disease spread in wild felids, with the aim of promoting conservation, and ultimately minimizing disease outbreaks in wildlife, domestic animals, and humans.

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research project

Feline Immunodeficiency Virus (FIV)

Cats infected with FIV, much like humans with HIV, suffer from oral disease. We are assessing how a novel combination antiretroviral therapy impacts infection, periodontal disease, and the cat's oral microbiome. This study is possible with the collaboration of microbiome experts, disease ecologists, veterinary dentists, veterinary immunologists and pathologists, and lab animal veterinarians.

research project

Microsporum Canis

M. canis is the primary pathogen in approximately 90% of Dermatophytosis cases in cats. Because the infection impacts the most adoptable (i.e. kittens), it can be a devastation in shelters. The infection can also be zoonotic and infects people worldwide. Our lab is currently investigating potential virulence genes in M. canis and developing a rapid point-of-care diagnostic for this agent.

research project

Diagnostics

The VandeWoude lab focuses on an array of pathogen testing through a variety of assays including conventional PCR, qPCR, ELISA, and multiplex bead based immunoassay. Current pathogens in our screening portfolio is feline foamy virus, feline gammaherpesvirus, feline immunodeficiency virus, puma and bobcat lentivirus, feline panleukopenia virus, and feline leukemia virus.

Publications

Endogenous feline leukemia virus siRNA transcription may interfere with exogenous FeLV infection.

Chiu ES, McDonald CA, VandeWoude S.
J Virol. 2021 Sep 8:JVI0007021. doi: 10.1128/JVI.00070-21. Online ahead of print. PMID: 34495702

Association Between COVID-19 Exposure and Self-reported Compliance With Public Health Guidelines Among Essential Employees at an Institution of Higher Education in the US.

Nelson TL, Fosdick BK, Biela LM, Schoenberg H, Mast S, McGinnis E, Young MC, Lynn L, Fahrner S, Nolt L, Dihle T, Quicke K, Gallichotte EN, Fitzmeyer E, Ebel GD, Pabilonia K, Ehrhart N, VandeWoude S.
JAMA Netw Open. 2021 Jul 1;4(7):e2116543. doi: 10.1001/jamanetworkopen.2021.16543. PMID: 34287634

Durable Antibody Responses in Staff at Two Long-Term Care Facilities, during and Post SARS-CoV-2 Outbreaks.

Gallichotte EN, Nehring M, Young MC, Pugh S, Sexton NR, Fitzmeyer E, Quicke KM, Richardson M, Pabilonia KL, Ehrhart N, Fosdick BK, VandeWoude S, Ebel GD.
Microbiol Spectr. 2021 Sep 3;9(1):e0022421. doi: 10.1128/Spectrum.00224-21. Epub 2021 Jul 21. PMID: 34287058

Feline Leukemia Virus (FeLV) Endogenous and Exogenous Recombination Events Result in Multiple FeLV-B Subtypes during Natural Infection.

Erbeck K, Gagne RB, Kraberger S, Chiu ES, Roelke-Parker M, VandeWoude S.
J Virol. 2021 Aug 25;95(18):e0035321. doi: 10.1128/JVI.00353-21. Epub 2021 Aug 25. PMID: 34232703

Serum Samples from Co-Infected and Domestic Cat Field Isolates Nonspecifically Bind FIV and Other Antigens in Enzyme-Linked Immunosorbent Assays.

Moskaluk A, Nehring M, VandeWoude S.
Pathogens. 2021 May 28;10(6):665. doi: 10.3390/pathogens10060665. PMID: 34071706

more publications
57 undergraduate and graduate students mentored
114+ manuscripts published in scientific journals since 2000
69 grants and awards totaling over $24 million in funding

People

Sue VandeWoude, D.V.M.

Lab Principal Investigator [PI]
University Distinguished Professor
Director, One Health Institute at Colorado State University

Mary Nehring, M.P.A.

Research Associate III
Lab Manager

Lauren Darlington

Research Associate I

Jeffrey Kim, D.V.M.

Postdoctoral Fellow

Chris Kozakiewicz, Ph.D.

Postdoctoral Fellow

Alex Moskaluk, D.V.M.

Postdoctoral Fellow

Laura Bashor

Graduate Research Assistant

Jordan Hoffman

Graduate Research Assistant

Treana Mayer

Graduate Research Assistant

Megan Conry

Veterinarian Summer Student

Sam Hilty

M.P.H. Student Researcher

Henry Dunkleberger

Student Researcher

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