Woerman Lab

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Publications

The role of α-synuclein prion strains in Parkinson’s disease and multiple system atrophy.
Khedmatgozar CR, Holec SAM,Woerman AL. PLoS Pathog. 2024 Jan 25;20(1):e1011920. doi: 10.1371/journal.ppat.1011920. eCollection 2024 Jan. PMID: 38271292

CBD and PSP cell-passaged Tau Seeds Generate Heterogeneous Fibrils with A sub-population Adopting Disease Folds.
Zeng Z, Vijayan V, Tsay K, Frost MP, Quddus A, Albert A, Vigers M, Woerman AL, Han S.
bioRxiv. 2023 Jul 21:2023.07.19.549721. doi: 10.1101/2023.07.19.549721. Preprint. PMID: 37502998

The E46K mutation modulates α-synuclein prion replication in transgenic mice.
Holec SAM, Lee J, Oehler A, Batia L, Wiggins-Gamble A, Lau J, Ooi FK, Merz GE, Wang M, Mordes DA, Olson SH, Woerman AL. PLoS Pathog. 2022 Dec 1;18(12):e1010956. doi: 10.1371/journal.ppat.1010956. eCollection 2022 Dec. PMID: 36454879

Multiple system atrophy prions transmit neurological disease to mice expressing wild-type human α-synuclein.
Holec SAM, Lee J, Oehler A, Ooi FK, Mordes DA, Olson SH, Prusiner SB, Woerman AL. Acta Neuropathol. 2022 Oct;144(4):677-690. doi: 10.1007/s00401-022-02476-7. Epub 2022 Aug 26.PMID: 36018376

Consequences of variability in α-synuclein fibril structure on strain biology.
Holec SAM, Liu SL, Woerman AL. Acta Neuropathol. 2022 Mar;143(3):311-330. doi: 10.1007/s00401-022-02403-w. Epub 2022 Feb 4.PMID: 35122113

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People

Amanda Woerman
Amanda Woerman, P.h.D

Lab Principle Investigator
Associate Professor

Sara Hammerstrom, Ph.D.

Postdoctoral Fellow

Benjamin Schneider

Research Associate II

Chase Khematgozar Headshot
Chase Khedmatgozar, M.S.

Graduate Research Assistant

Klaudia Poplawski

Graduate Research Assistant

Schelbe Schure
Shelbe Schure

Graduate Research Assistant

EMMA SZEGVARI
Emma Szegvari

Graduate Research Assistant
PhD/DVM Rotation Student

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You can include a slideshow (up to five slides) of whatever additional content the lab would like. Like the other slideshow block, use horizontal images and short descriptions.

You can include a slideshow (up to five slides) of whatever additional content the lab would like. Like the other slideshow block, use horizontal images and short descriptions.

news and updates view all

December 5, 2022 Misfolding Protein May Pave the Road to Personalized Medicine Approach

University of Massachusetts Amherst researchers, led by Amanda Woerman, make an amazing discovery that may lead to a more personalized approach for Multiple System Atrophy.
December 1, 2022 Protein mutation that causes Parkinson’s may prevent another neurodegenerative disease

Amanda Woerman finds that a mutation in the misfolding protein that causes Parkinson’s disease offers protection against multiple system atrophy.
November 18, 2022 Grant Will Support Amanda Woerman’s Innovative Gene Therapy Research Into Treatment For Fatal Neurodegenerative Diseases

The Tau Consortium of the Rainwater Charitable Foundation awards a grant to develop gene therapy for tauopathies to Amanda Woerman.

contact information

Office: Pathology room 228

Lab: Pathology rooms 218, 219

(970) 491-0505