Grants and Funding

National Institute of Health Administrative Supplement

1R01CA201112-01A1                                    Ryan (PI)                                                                                                                                                   

07/01/2019 – 06/30/2020

NIH Administrative Supplement – Novel approaches to develop microbial consortia for use as oral dietary supplements that advance colon health functions will include integrated functional profiles of species-composition identity with gene expression, proteins and metabolite products included in the formulation.

USDA-NIFA-National Institute of Food and Agriculture

004228-00002                                                 Ryan (PI)                                                                                                                                                                  

11/15/15 – 11/14/20

Rice Bran and Bean Metabolomes for Human Dietary Exposure Biomarkers

This project will identify dietary biomarkers of rice bran and navy bean consumption using biological samples collected from intervention trials conducted with these foods in children and adults.
Role: PI


National Institutes of Health- National Cancer Institute

1R01CA201112-01A1                                    Ryan (PI)                                                                                                                                                                   

07/01/16 – 06/30/21

Rice Bran Microbial Metabolism for Colon Chemoprevention

This project involves transfaunation of microbiota from humans fed rice bran as a novel dietary colon cancer chemoprevention strategy that will be evaluated using carcinogen induced colon cancer models.
Role: PI

Foundation Food and Agriculture Research

560631                                                                        Jablonski (PI), Ryan (Co-I)                                                                                                  

02/01/18 – 01/31/22

Foundation for Food and Agriculture Research, Integrating Community and Modeling Efforts to Evaluate the Impacts and Tradeoffs of Food System Interventions

The major goal of this project is to address the current volume of food wasted from loss of animals, post-harvest preservation, and with packaging into the marketplace.
Role: Co-I

Completed Research Support

CancerCure Foundation Pilot Award 

NA                                                                                           Ryan (PI)                                                                                                            

11/01/15 – 10/30/16        

Human Intestinal Tissue Biopsies for Ex Vivo Analysis

The purpose of this study is to identify healthy human colon tissue biomarkers
Role: PI


Global Health Grand Challenges Explorations - Bill and Melinda Gates Foundation Phase II Award and Supplement

OPP1043255                                                  Ryan (PI)                                                                                                                                                                   

05/17/12 – 12/31/16

Dietary Rice Bran Supplementation for Gut Mucosal Immunity and Healthy Rice Crop Improvement

The major goal of this project is to examine rice bran components from diverse rice varieties for nonspecific induction of gut mucosal immunity in response to enteric pathogens using mice and pigs, and to establish pilot feasibility and safety of rice bran intake in infants at risk for malnutrition and diarrheal disease.

University of Colorado Cancer Center 

NA                                                                                           Ryan (PI)                                                                                                     

08/01/14 – 07/31/15      

Clinical Cancer Control and Prevention Pilot Award

The major goal of this project is to pilot a combination dietary rice bran and navy bean powder intervention for 6 months in adults with colonic polyps, and to assess changes in colonic tissue biomarkers using samples collected from colonoscopy.

DOS-AID-Agency for International Development

AID-OAA-L-10-00001                        Ryan (PI)                                                                                                                                                                   

04/20/10 – 04/19/15

DOS-AID-Agency for International Development

Feed the Future Innovation Lab for Collaborative Research on Adapting Livestock Systems to Climate Change My major role in this project is to serve as the Nutrition Advisor for a number of associate awards to project PIs from U.S. and collaborating host country academic institutions, and to identify many ways for these international research and development projects to have indicators that relate to enhanced childhood nutrition, and for reducing the incidence and prevalence of stunting in developing “Feed the Future” countries.
Role: PI



R21-CA161472-02                             Ryan (Multi-PI, Weir)                                                                                                                        

08/01/12 – 08/31/14

Rice bran microbial metabolism for colon cancer prevention

Major goal of this study is to examine changes in the human stool microbiome and metabolome following dietary rice bran intake in a cohort of colon cancer survivors in Northern Colorado.
Role: Multi-PI


R03CA150070                                                Ryan (PI)                                                                                                                                                                   

04/01/10 – 03/31/12

Probiotic Metabolism of Rice Bran Phytochemicals for Cancer Prevention

The major goal of this study was to examine rice bran components and rice varieties that support growth of probiotics and to measure bioactivity of the metabolites produced following fermentation of rice bran using probiotic strains relevant to the gut.
Role: PI