National Institute of Health Administrative Supplement
1R01CA201112-01A1 Ryan (PI)
07/01/2019 – 06/30/2020
NIH Administrative Supplement – Novel approaches to develop microbial consortia for use as oral dietary supplements that advance colon health functions will include integrated functional profiles of species-composition identity with gene expression, proteins and metabolite products included in the formulation.
USDA-NIFA-National Institute of Food and Agriculture
004228-00002 Ryan (PI)
11/15/15 – 11/14/20
Rice Bran and Bean Metabolomes for Human Dietary Exposure Biomarkers
This project will identify dietary biomarkers of rice bran and navy bean consumption using biological samples collected from intervention trials conducted with these foods in children and adults.
Role: PI
National Institutes of Health- National Cancer Institute
1R01CA201112-01A1 Ryan (PI)
07/01/16 – 06/30/21
Rice Bran Microbial Metabolism for Colon Chemoprevention
This project involves transfaunation of microbiota from humans fed rice bran as a novel dietary colon cancer chemoprevention strategy that will be evaluated using carcinogen induced colon cancer models.
Role: PI
Foundation Food and Agriculture Research
560631 Jablonski (PI), Ryan (Co-I)
02/01/18 – 01/31/22
Foundation for Food and Agriculture Research, Integrating Community and Modeling Efforts to Evaluate the Impacts and Tradeoffs of Food System Interventions
The major goal of this project is to address the current volume of food wasted from loss of animals, post-harvest preservation, and with packaging into the marketplace.
Role: Co-I
Completed Research Support
CancerCure Foundation Pilot Award
NA Ryan (PI)
11/01/15 – 10/30/16
Human Intestinal Tissue Biopsies for Ex Vivo Analysis
The purpose of this study is to identify healthy human colon tissue biomarkers
Role: PI
Global Health Grand Challenges Explorations - Bill and Melinda Gates Foundation Phase II Award and Supplement
OPP1043255 Ryan (PI)
05/17/12 – 12/31/16
Dietary Rice Bran Supplementation for Gut Mucosal Immunity and Healthy Rice Crop Improvement
The major goal of this project is to examine rice bran components from diverse rice varieties for nonspecific induction of gut mucosal immunity in response to enteric pathogens using mice and pigs, and to establish pilot feasibility and safety of rice bran intake in infants at risk for malnutrition and diarrheal disease.
University of Colorado Cancer Center
NA Ryan (PI)
08/01/14 – 07/31/15
Clinical Cancer Control and Prevention Pilot Award
The major goal of this project is to pilot a combination dietary rice bran and navy bean powder intervention for 6 months in adults with colonic polyps, and to assess changes in colonic tissue biomarkers using samples collected from colonoscopy.
DOS-AID-Agency for International Development
AID-OAA-L-10-00001 Ryan (PI)
04/20/10 – 04/19/15
DOS-AID-Agency for International Development
Feed the Future Innovation Lab for Collaborative Research on Adapting Livestock Systems to Climate Change My major role in this project is to serve as the Nutrition Advisor for a number of associate awards to project PIs from U.S. and collaborating host country academic institutions, and to identify many ways for these international research and development projects to have indicators that relate to enhanced childhood nutrition, and for reducing the incidence and prevalence of stunting in developing “Feed the Future” countries.
Role: PI
NIH NCI
R21-CA161472-02 Ryan (Multi-PI, Weir)
08/01/12 – 08/31/14
Rice bran microbial metabolism for colon cancer prevention
Major goal of this study is to examine changes in the human stool microbiome and metabolome following dietary rice bran intake in a cohort of colon cancer survivors in Northern Colorado.
Role: Multi-PI
NCI-NIH
R03CA150070 Ryan (PI)
04/01/10 – 03/31/12
Probiotic Metabolism of Rice Bran Phytochemicals for Cancer Prevention
The major goal of this study was to examine rice bran components and rice varieties that support growth of probiotics and to measure bioactivity of the metabolites produced following fermentation of rice bran using probiotic strains relevant to the gut.
Role: PI